Steve Harrison

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When looking out across the intellectual landscape of HCI, how do we make sense of it? More importantly, how do we evaluate what constitutes legitimate investigation? As an interdisciplinary field, HCI faces challenges in incorporating sometimes conflicting intellectual approaches. While new approaches enrich our view of interaction, they can also lead to(More)
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA(1) is a G(i)-coupled seven transmembrane receptor with high affinity for lysophosphatidic acid. Although LPA(1) is expressed in several peripheral(More)
Department of Computer Science and (by courtesy) Art and Art History, Virginia Tech, 121 VTKW II, 2202 Kraft Dr – MC 0106 Blacksburg, VA 24060, USA b Information Science and Science & Technology Studies, Cornell University, 301 College Ave., Ithaca, NY 14580, USA Department of Computer Science and (by courtesy) Psychology, Virginia Tech, 123 VTKW II, 2202(More)
BACKGROUND & AIMS Liver biopsy is the only reliable way of diagnosing and staging NASH but its invasive nature limits its use. Plasma caspase-generated cytokeratin-18 fragments (CK-18) have been proposed as a non-invasive alternative. We studied its clinical value in a large multiethnic NAFLD population and examined its relationship to(More)
BACKGROUND Routine handwashing has been proven to decrease incidence of health care-associated infections, including methicillin-resistant Staphylococcus aureus (MRSA), spawning numerous attempts to "advertise" its importance. However, most control measures fail to evaluate systematically the efficacy of handwashing initiatives. The purpose of this study(More)
Video conferencing allows distance-separated family members to interact somewhat akin to being together at the same place and time. Yet most video conferencing systems are designed for phone-like calls between only two locations. Using such systems for long interactions or social gatherings with multiple families is cumbersome, if not impossible. For this(More)
Affinity diagramming is a commonly used contextual design practice for which many tools have been developed. However, experts and novices alike eschew tool use, instead using traditional paper and whiteboard methods. This paper presents observations of traditional affinity diagramming sessions, focusing on three areas of consideration—shared awareness,(More)
The design space for intimate partners has largely been populated with technologies that support <i>distant partners</i> via <i>abstracted presence</i>. We seek to expand the design space to include a wider range of potential users and designs. To this end, we present findings from qualitative interviews with Family Studies experts in the form of a(More)
Collaborative drumming is a creative human activity that requires a high degree of coordination among the participants. In this study, inexperienced drummer and experienced drummer participants were paired with a computer or experienced human drummer counterpart and given the task of producing musical rhythms on the fly. We found differing patterns of music(More)
Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. PI4KA has also been linked to endoplasmic reticulum exit sites and generation of plasma membrane phosphoinositides. Here, we developed highly specific and potent inhibitors of PI4KA and conditional(More)