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When looking out across the intellectual landscape of HCI, how do we make sense of it? More importantly , how do we evaluate what constitutes legitimate investigation? As an interdisciplinary field, HCI faces challenges in incorporating sometimes conflicting intellectual approaches. While new approaches enrich our view of interaction, they can also lead to(More)
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA(1) is a G(i)-coupled seven transmembrane receptor with high affinity for lysophosphatidic acid. Although LPA(1) is expressed in several peripheral(More)
BACE1 is a key enzyme in the generation of Abeta, the major component of senile plaques in the brains of Alzheimer's disease patients. We have generated transgenic mice expressing human BACE1 with the Cam Kinase II promoter driving neuronal-specific expression. The transgene contains the full-length coding sequence of human BACE1 preceding an internal(More)
Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. PI4KA has also been linked to endoplasmic reticulum exit sites and generation of plasma membrane phosphoinositides. Here, we developed highly specific and potent inhibitors of PI4KA and conditional(More)
BACKGROUND & AIMS Liver biopsy is the only reliable way of diagnosing and staging NASH but its invasive nature limits its use. Plasma caspase-generated cytokeratin-18 fragments (CK-18) have been proposed as a non-invasive alternative. We studied its clinical value in a large multiethnic NAFLD population and examined its relationship to(More)
Computing education has permeated virtually all disciplines, expanding learning with new technology and an updated definition of literacy that includes computational thinking. As opportunities for multidisciplinary courses that include computing increase, so do the challenges placed on faculty to develop such courses and the required computing expertise(More)
Collaborative drumming is a creative human activity that requires a high degree of coordination among the participants. In this study, inexperienced drummer and experienced drummer participants were paired with a computer or experienced human drummer counterpart and given the task of producing musical rhythms on the fly. We found differing patterns of music(More)
Mobile, digital technologies are thought to augment and transcend the limits of our places, yet they raise the issue of what our places are. PlaceMark is a simple, distributed col-laborative authoring environment constructed in conjunction with a site-specific writing activity. Here, we examine it as a cultural probe, investigating how new media students(More)
BACKGROUND Routine handwashing has been proven to decrease incidence of health care-associated infections, including methicillin-resistant Staphylococcus aureus (MRSA), spawning numerous attempts to "advertise" its importance. However, most control measures fail to evaluate systematically the efficacy of handwashing initiatives. The purpose of this study(More)