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Recordings were made from single neurons in the hand area of the human motor cortex while peripheral physiologic stimuli were applied. Such cells responded only to active and passive hand movements. Tactile and autditory (click) stimuli were itneffective. The majority of cells were activated only by movements of the contralateral hand, but a significant(More)
In the past 2 years, an increasing number of reports have appeared in the medical literature that suggest that the use of bisphosphonates, especially intravenous bisphospho-nates, is associated with osteonecrosis of the jaw (ONJ). The majority of these reports are in patients with multiple myeloma, breast cancer, or other malignancies. In connection with(More)
A method of surgical management for intractable epilepsy is described. The essential features are: 1) all surgical manipulation is carried out under general, rather than local, anesthesia; 2) the sensorimotor region is readily identified in the anesthetized patient by recording cortical sensory evoked responses; and 3) the epileptogenic focus is localized(More)
An elucidation of the interaction between the bone marrow microenvironment and hematopoietic stem cells is critical to the understanding of the molecular basis of stem cell self renewal and differentiation. This interaction is dependent, at least in part, on direct cell to cell contact or cellular adhesion to extracellular matrix proteins. Long-term bone(More)