Steve G Parker

Learn More
1. The clinicopathological features of endotoxaemia have been ascribed to cytotoxic mediators such as tumour necrosis factor, interleukins and eicosanoids. Macrophages, particularly Kupffer cells, are an important source of these mediators. Mortality from endotoxaemia is highly age related. 2. These studies focus on the role of hepatic Kupffer cells in the(More)
At their clinical doses, current antipsychotic agents share the property of both dopamine D(2) and D(3) receptor blockade. However, a major disadvantage of many current medications are the observed extrapyramidal side-effects (EPS), postulated to arise from D(2) receptor antagonism. Consequently, a selective dopamine D(3) receptor antagonist could offer an(More)
Studies were conducted to determine possible development, and underlying mechanisms, of tolerance to the hypotensive effects of ropinirole (4-[2-(dipropylamino)ethyl]-1-3-dihydro-2H-indol-2-one HCl), a selective dopamine receptor agonist, following twice daily oral administration to cynomolgus monkeys and spontaneously hypertensive rats (SHR). Tolerance to(More)
Today, scientists, engineers, and medical researchers routinely use computers to simulate complex physical phenomena. Such simulations present new challenges for computational scientists, including the need to effectively analyze and visualize complex threedimensional data. As simulations become more complex and produce larger amounts of data, the(More)
The systemic cardiovascular effects of a novel 5-hydroxtryptamine (5-HT)(1B/1D)-receptor agonist were investigated in the anaesthetised dog. SB 209509 (VML 251) was more potent than sumatriptan in producing increases in carotid vascular resistance after intravenous administration and was similar in potency to sumatriptan after sequential intraduodenal(More)
Brief description: We show how digital technologies are used in SCIRun, a computational programming and steering environment. We explore these technologies as applied to problems in computational medicine and computational uid dynamics. Several digital technologies are explored including graphical user interfaces, high performance graphics hardware, 3D(More)
Neutropenic enterocolitis affects the ileocaecal region of the bowel and is characterised by intense thickening and oedema with mucosal necrosis. It is associated with agranulocytosis, often with Clostridium septicum infection, and commonly occurs in patients with acute leukaemia, many of whom have been treated with cytosine arabinoside. The strong(More)
  • 1