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Time Warp's optimistic scheduling requires the maintenance of simulation state history to support rollback in the event of causality violations. State history, and the ability to rollback the simulation, can provide unique functionality for human-in-the-loop simulation environments. This paper investigates the use of Time Warp to output valid simulation(More)
SimKit is a C++ class library that is designed for fast discrete event simulation. SimKit presents a simple, elegant logical process view of simulation enabling both sequential and parallel execution without code changes to application models. The sequential executive performs well on a variety of UNIX platforms and facilitates debugging and testing. The(More)
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide(More)
Optimistic parallel discrete event simulation (PDES) uses a state history trail to support rollback. State saving strategies range from making a complete copy of a model's state after each event execution to recording a sequence of each state modification made during event execution. The former is called copy state saving (CSS) and the latter incremental(More)
A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery(More)
In this paper we see that some kinds of movement in Tagalog require the moved DP to be 3 rd person. I show that we can account for such requirements if we follow Anagnostopoulou (2003, 2005) in associating Person-Case effects with multiple Agree operations by a single Probe, and Rackowski and Richards (to appear) in positing such multiple Agree relations in(More)
The use of shared memory computers to implement the TimeWarp algorithm for distributed discrete event simulation is discussed. Actual experience on an implementation for the KSR-1 is described and compared with another implementation on explicit message passing machines. Modifications necessary to achieve good speedup are described. Performance results on(More)
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent(More)
Throughout the development of syntactic theory, it has been widely assumed that sentence structures are represented as a certain type of graph, called a tree. On the basis of a variety of diagnostics, the words in a sentence have been taken to clump together to form hierarchically organized subgroupings, called constituents. Thus, the sentence every child(More)