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CYP11A, the gene encoding p450scc, a key enzyme in steroid biosynthesis, is a strong biological candidate for polycystic ovary syndrome (PCOS) susceptibility. Four of the five published studies that have examined CYP11A for evidence of linkage and/or association have reported significant relationships with polycystic ovary (PCO) status and/or serum(More)
CONTEXT Variation at the insulin gene VNTR (variable number tandem repeat) minisatellite has been reported to be associated with polycystic ovary syndrome (PCOS), but findings have been inconsistent and all studies have featured small sample sizes. OBJECTIVE To gain a robust understanding of the role of the INS-VNTR in PCOS susceptibility. DESIGN(More)
Time Warp's optimistic scheduling requires the maintenance of simulation state history to support rollback in the event of causality violations. State history, and the ability to rollback the simulation, can provide unique functionality for human-in-the-loop simulation environments. This paper investigates the use of Time Warp to output valid simulation(More)
OBJECTIVE There are close phenotypic similarities between cortisone reductase deficiency (CRD), a rare abnormality of cortisone metabolism, and polycystic ovary syndrome (PCOS). As there is evidence that CRD results from digenic mutations involving the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) and hexose-6-phosphate dehydrogenase(More)
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide(More)
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for(More)
SimKit is a C++ class library that is designed for fast discrete event simulation. SimKit presents a simple, elegant logical process view of simulation enabling both sequential and parallel execution without code changes to application models. The sequential executive performs well on a variety of UNIX platforms and facilitates debugging and testing. The(More)
Variation within the calpain-10 gene (CAPN10) has been proposed to account for linkage to type 2 diabetes on chromosome 2q in Mexican-Americans, and associations with diabetes have been reported in several other populations. Given the epidemiological, physiological, and genetic overlap between type 2 diabetes and polycystic ovary syndrome (PCOS), CAPN10(More)
OBJECTIVE To summarize promising areas of investigation into polycystic ovary syndrome (PCOS) and to stimulate further research in this area. DESIGN Summary of a conference held by international researchers in the field of polycystic ovary syndrome. RESULTS Potential areas of further research activity include the analysis of predisposing conditions that(More)
A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery(More)