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  • Sirwan M. Hadad, Takayuki Iwamoto, +10 authors Alastair M. Thompson
  • Medicine
  • Breast Cancer Research and Treatment
  • 2011 (First Published: 1 August 2011)
  • Metformin may reduce the incidence of breast cancer and enhance response to neoadjuvant chemotherapy in diabetic women. This trial examined the effects of metformin on Ki67 and gene expression inContinue Reading
  • M. R. Barnes, Steve Deharo, Russell J. Grocock, James R Brown, Philippe Sanseau
  • Biology, Medicine
  • Expert opinion on biological therapy
  • 2007 (First Published: 1 September 2007)
  • Evidence is emerging that micro RNA (miRNA) is an important and potentially polymorphic regulatory layer for silencing gene expression in vivo. Knowledge of miRNA targeting may help to elucidate theContinue Reading
  • Charlie Gourley, Caroline O. Michie, +14 authors Richard D Kennedy
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2011 (First Published: 20 May 2011)
  • 5000 Background: Despite histological heterogeneity and evidence of some molecular subtypes (e.g. BRCA1/2-deficient) EOC continues to be treated as a single disease. Using unsupervised hierarchicalContinue Reading
  • Jude Marie Mulligan, Leigh Anne Hill, +17 authors Richard D Kennedy
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2011 (First Published: 20 May 2011)
  • 10511 Background: Loss of a functional DNA-damage response (DDR) sensitizes tumors to DNA-damaging as well as targeted therapeutics such as PARP-1 inhibitors. However, there is no assay to detect DDRContinue Reading