Steve DeMartino

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RATIONALE Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. OBJECTIVES To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. METHODS In bronchial biopsies from 21 normal subjects, 11 subjects with(More)
We reasoned that a prospective assessment of glucocorticoid withdrawal in subjects with asthma would provide insight into the basis for flares of the disease. We therefore enrolled 25 subjects with moderate persistent asthma and treated them for 30 days with inhaled fluticasone propionate (1,760 microg/day) followed by a withdrawal period that lasted until(More)
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