Steve De Rosa

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Blood and tissue are composed of many functionally distinct cell subsets. In immunological studies, these can be measured accurately only using single-cell assays. The characterization of these small cell subsets is crucial to decipher system-level biological changes. For this reason, an increasing number of studies rely on assays that provide single-cell(More)
BACKGROUND Elevated risk of HIV-1 infection among recipients of an adenovirus serotype 5 (Ad5)-vectored HIV-1 vaccine was previously reported in the Step HIV-1 vaccine efficacy trial. We assessed pre-infection cellular immune responses measured at 4 weeks after the second vaccination to determine their roles in HIV-1 infection susceptibility among Step(More)
Health, education and social services are placing increasing emphasis on preventing abuse and neglect by early intervention to support families where children and young people may be at risk. Dental hygienist and dental assistants, like all other health professionals, can have a part in recognizing and preventing children from those who would cause them(More)
Methods This retrospective analysis included data from 1218 healthy, HIV-1 uninfected adults enrolled in 10 DNA HIV vaccine clinical trials conducted within the HIV Vaccine Trials Network. HIV-specific T-cell responses from peripheral blood mononuclear cells were measured using validated IFN-g ELISpot and intracellular cytokine staining assays. The effects(More)
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