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- Gustavo Matute-Bello, Gregory P Downey, +4 authors Wolfgang Michael Kuebler
- American journal of respiratory cell and…
- 2011
Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main features of acute lung injury in animal models. A Committee was organized to determine the main features… (More)
- Tasha E Fingerlin, E. A. Murphy, +47 authors David A. Schwartz
- Nature Genetics
- 2013
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication… (More)
- Max A. Seibold, Anastasia L. Wise, +26 authors David A. Schwartz
- The New England journal of medicine
- 2011
BACKGROUND
The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk.
METHODS
Using a genomewide linkage scan, we detected linkage… (More)
- Elvira Stacher, Brian B Graham, +8 authors Rubin M. Tuder
- American journal of respiratory and critical care…
- 2012
RATIONALE
The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown.
OBJECTIVES
To assess the spectrum of pulmonary vascular… (More)
- Ivana V. Yang, Christopher Coldren, +14 authors David A. Schwartz
- Thorax
- 2013
BACKGROUND
Idiopathic pulmonary fibrosis (IPF) is an untreatable lung disease with a median survival of only 3-5 years that is diagnosed using a combination of clinical, radiographic and pathologic… (More)
- Edward S. Chen, Zhimin Song, +7 authors David Robert Moller
- American journal of respiratory and critical care…
- 2010
RATIONALE
The critical innate immune mechanisms that regulate granulomatous inflammation in sarcoidosis are unknown. Because the granuloma-inducing component of sarcoidosis tissues has… (More)
- Carlyne D Cool, Steve D. Groshong, Pradeep R. Rai, Peter M Henson, J. Scott Stewart, K Kirkman - Brown
- American journal of respiratory and critical care…
- 2006
BACKGROUND
Usual interstitial pneumonia (UIP), the pathologic correlate of idiopathic pulmonary fibrosis, contains characteristic discrete areas of fibroblasts, myofibroblasts, and newly formed… (More)
- Barbara Tringler, Carol J. Gup, +4 authors Kenneth R. Shroyer
- Human pathology
- 2004
p16(INK4a) is known to play a critical role as a negative regulator of cell cycle progression and differentiation by controlling the activity of the tumor-suppressor protein pRb. The present study… (More)
- Seth J. Kligerman, Steve D. Groshong, K Kirkman - Brown, David A. Lynch
- Radiographics : a review publication of the…
- 2009
Nonspecific interstitial pneumonia (NSIP) has variable clinical, pathologic, and radiologic manifestations. Cellular and fibrotic NSIP are the two main histologic subtypes and differ from one another… (More)
- Aryeh Fischer, Jeffrey J. Swigris, +7 authors K Kirkman - Brown
- Chest
- 2008
PURPOSES
To evaluate the pathologic patterns, clinical features, and survival among subjects with scleroderma (ie, systemic sclerosis [SSc]) and clinically significant interstitial lung disease (ILD)… (More)