Steve Carlson

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Designers traditionally think that the way to improve the design cycle is by moving to higher levels of design abstraction. This paper discusses how new EDA tools are changing the f orrn and eff activeness of design reuse as a strategy to increase design quality and engineering productivity Why reuse designs? Increasing competitiveness in today's(More)
BACKGROUND G protein-coupled receptors (GPCRs) constitute one of the largest groupings of eukaryotic proteins, and represent a particularly lucrative set of pharmaceutical targets. They play an important role in eukaryotic signal transduction and physiology, mediating cellular responses to a diverse range of extracellular stimuli. The phylum Platyhelminthes(More)
Pathogenic Salmonella species initiate infection of a host by inducing their own uptake into intestinal epithelial cells. An invasive phenotype is conferred to this pathogen by a number of proteins that are components of a type III secretion system. During the invasion process, the bacteria utilize this secretion system to release proteins that enter the(More)
BACKGROUND Schistosomes are parasitic helminths that infect humans through dermo-invasion while in contaminated water. Salmonella are also a common water-borne human pathogen that infects the gastrointestinal tract via the oral route. Both pathogens eventually enter the systemic circulation as part of their respective disease processes. Concurrent(More)
Salmonella carriage is an insidious problem for the poultry industry. While most Salmonella serotypes are avirulent in poultry, these bacteria can contaminate chicken meat during processing, leading to one of the most important food safety hazards. In this study, we examined the anti-Salmonella effects of Diamond V Original XPC™ (XPC) included in the(More)
The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively(More)
This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, β-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrophic lateral sclerosis. Minocycline has shown promise in(More)
A warm welcome from the Editorial desk of the ONTC's newsletter " Prism ". It is our pleasure to bring to you this fourth edition of PRISM – ONTC's quarterly newsletter. The current issue focuses on a wide variety of subjects – from covering Stanford University's Photonics and Networking Research laboratory, to the industry work in 802.1 as well as MPLS-TP(More)
Essentially all mathematics graduate students, as well as many undergraduate math majors, at some point in their studies learn the importance of the axiom of choice and some of its equivalent versions. The author of this note was a graduate student studying topology in the 1970's, when the current " mathematical humor'' in my group involved riddles like the(More)