Steve Carlson

Learn More
Designers traditionally think that the way to improve the design cycle is by moving to higher levels of design abstraction. This paper discusses how new EDA tools are changing the f orrn and eff activeness of design reuse as a strategy to increase design quality and engineering productivity Why reuse designs? Increasing competitiveness in today's(More)
BACKGROUND G protein-coupled receptors (GPCRs) constitute one of the largest groupings of eukaryotic proteins, and represent a particularly lucrative set of pharmaceutical targets. They play an important role in eukaryotic signal transduction and physiology, mediating cellular responses to a diverse range of extracellular stimuli. The phylum Platyhelminthes(More)
BACKGROUND Schistosomes are parasitic helminths that infect humans through dermo-invasion while in contaminated water. Salmonella are also a common water-borne human pathogen that infects the gastrointestinal tract via the oral route. Both pathogens eventually enter the systemic circulation as part of their respective disease processes. Concurrent(More)
The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively(More)
This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, β-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrophic lateral sclerosis. Minocycline has shown promise in(More)
The EDA industry is entering its third decade with more software suppliers than ever before, automating smaller and smaller pieces of the design flow. The question invariably is whether an emerging EDA company, or any semiconductor industry supplier for that matter, can remain independent and grow large enough to rival the big industry players. In fact,(More)
  • 1