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Genetic deafness is common, affecting about 1 in 2,000 births. Many of these show primary abnormalities of the sensory neuroepithelia of the inner ear, as do several hearing-impaired mouse mutants, suggesting that genes involved in sensory transduction could be affected. Here we report the identification of one such gene, the mouse shaker-1 (sh1) gene.(More)
Two types of Usher syndrome, a blindness-deafness disorder, result from mutations in the myosin VIIa gene. As for most other unconventional myosins, little is known about the function or functions of myosin VIIa. Here, we studied the photoreceptor cells of mice with mutant myosin VIIa by electron immunomicroscopy and microscopic autoradiography. We found(More)
Mutations in Myo7a cause hereditary deafness in mice and humans. We describe the effects of two mutations, Myo7a(6J) and Myo7a(4626SB), on mechano-electrical transduction in cochlear hair cells. Both mutations result in two major functional abnormalities that would interfere with sound transduction. The hair bundles need to be displaced beyond their(More)
Genome sequences are essential tools for comparative and mutational analyses. Here we present the short read sequence of mouse chromosome 17 from the Mus musculus domesticus derived strain A/J, and the Mus musculus castaneus derived strain CAST/Ei. We describe approaches for the accurate identification of nucleotide and structural variation in the genomes(More)
By 1958, a model of human behavior capable of serving as the microlevel foundation for organizational and policy studies was in place. The scientific soundness of that model is un-questioned, yet the fundamentals of that behavioral model of choice have not yet been incorporated into political science. Much analysis relies on models of rational maximization(More)
iii For my wife, Cathy Without her love, patience, and support, this dissertation would never have existed. Acknowledgments The rst person to thank, of course, is my advisor, Jim Cohoon. His guidance, advice, and support have been invaluable throughout my doctoral studies. I also thank Jee Salowe, with whom I had many discussions on much of the material(More)
The merit of international convergence of bank capital requirements in the presence of divergent closure policies of di¡erent central banks is examined. The lack of a complementary variation between minimum bank capital requirements and regulatory forbearance leads to a spillover from more forbearing to less forbearing economies and reduces the competitive(More)
3 Interagency working: rationale and definitions 13 4 Interagency working as co-configuration 17 5 Object-orientated analyses of interagency working 26 6 Bureaucratic analyses of interagency working 37 7 Knots, teams and networks 39 8 Boundary-crossing 44 9 Conclusion 48 References 49 Acknowledgments The Learning in and for Interagency Working project is(More)