Steve Arcona

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PURPOSE The goal of this work was to assess the effect of comorbidities on medical care use and costs among patients with partial seizure disorder who are also refractory to initial antiepileptic drug (AED) monotherapy. METHODS Retrospective data from the PharMetrics managed care claims database were collected for adult patients treated with AED(More)
BACKGROUND The use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been associated with an increased risk of pneumonia in controlled clinical trials and case-control analyses. OBJECTIVE Using claims databases as a research model of real-world diagnosis and treatment, to determine if the use and dose of inhaled(More)
BACKGROUND Proportion of days covered (PDC), a commonly used adherence metric, does not provide information about the longitudinal course of adherence to treatment over time. Group-based trajectory model (GBTM) is an alternative method that overcomes this limitation. METHODS The statistical principles of GBTM and PDC were applied to assess adherence(More)
BACKGROUND Comparative effectiveness research (CER) often includes observational studies utilizing administrative data. Multiple conditioning methods can be used for CER to adjust for group differences, including difference-in-differences (DiD) estimation. OBJECTIVE This study presents DiD and demonstrates how to apply this conditioning method to estimate(More)
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