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OBJECTIVE To determine whether HLA and autoimmunity contribute to the pathogenesis of Blau syndrome (familial granulomatous arthritis, uveitis, and rash) and evaluate whether this condition is related to sarcoidosis. DESIGN Large family survey. SETTING General community, Green Bay, Wis, and two tertiary care medical centers in Philadelphia, Pa. (More)
OBJECTIVES This study reports findings from the first-ever systematic enumeration of homeless population size using data previously collected from administrative records of homeless services providers in nine US jurisdictions over a one year period. As such, it provides the basis for establishing an ongoing measure of the parameters of the homeless(More)
This paper puts forth an explanation of the recent escalation of violent crime in Colombia. The paper considers three implicit models that isolate different types of externalities among criminals. In the first model criminals make crime more appealing to nearby residents by congesting the law enforcement system and hence lowering the probability of(More)
Although common in tropical regions, pyomyositis is rare in the continental United States. Fewer than 50 cases have been reported to date. It is characterized by suppuration of large muscle groups that can, if not quickly and appropriately treated, lead to sepsis and death. Diagnosis can be difficult secondary to the atypical appearance of the abscess(More)
A family with a syndrome consisting of granulomatous arthritis, uveitis, and rash was first described in 1985. Another family with the same syndrome was described subsequently in 1990. The condition, in both families, is clinically different from sarcoidosis. To verify whether the granulomas in such patients also could be distinctive, we performed(More)
Blau syndrome is an autosomal dominant syndrome characterized by arthritis, uveitis, skin rash, granuloma, and camptodactyly. It has overlapping symptoms with sarcoidosis and rheumatoid arthritis. Our study was directed toward determining the role of cytokines in granuloma formation in Blau syndrome. Antigenic stimulation usually follows two pathways: Th-1,(More)
Over the past thirty years, many states have abolished parole boards, which traditionally have had the discretion to release inmates before the expiration of their full sentence, in favor of fixed-sentence regimes in which the original sentence is binding. However, if prison time lowers recidivism risk and if parole boards can accurately estimate inmates'(More)