Steve A. Edgley

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1. The properties of interneurones located in the 4th lumbar segment of the cat spinal cord (L4 interneurones) have been investigated by intracellular and extracellular recording from individual neurones. The study focused on interneurones projecting to hind-limb motor nuclei and/or interposed in pathways from group II muscle afferents. The projection to(More)
1. A powerful projection from group II muscle afferents of hind-limb muscles to the 3rd, 4th and 5th segments of the lumbar spinal cord has been demonstrated by focal synaptic field potential recording. 2. Field potentials were found at two locations: one in the dorsal horn (Rexed's laminae IV and V) and the other in the intermediate zone and ventral horn(More)
While the synaptic properties of Golgi cell-mediated inhibition of granule cells are well studied, less is known of the afferent inputs to Golgi cells so their role in information processing remains unclear. We investigated the responses of cerebellar cortical Golgi cells and Purkinje cells in Crus I and II of the posterior lobe cerebellar hemisphere to(More)
Interneurones interconnecting the two sides of the spinal cord (commissural interneurones) are critically important for interlimb coordination, but little is known about their organization. We have examined the inputs to commissural interneurones located in the midlumbar segments with projections to contralateral motor nuclei, aiming to determine whether(More)
1. Extracellular recordings have been obtained from 134 units in the paravermal cortex of lobule V in the anterior lobe of the cerebellum in free-to-move cats. Each unit discharged action potentials in a characteristic pattern with no complex spikes. Previous investigators have described such discharges and have assigned them to Golgi cells. We provide(More)
Damage to the corticospinal tract is a leading cause of motor disability, for example in stroke or spinal cord injury. Some function usually recovers, but whether plasticity of undamaged ipsilaterally descending corticospinal axons and/or brainstem pathways such as the reticulospinal tract contributes to recovery is unknown. Here, we examined the(More)
The postnatal development of corticospinal projections was investigated in 11 macaques by means of the anterograde transport of wheat germ agglutin-horseradish peroxidase injected into the primary motor cortex hand area. Although the fibers of the corticospinal tract reached all levels of the spinal cord white matter at birth, their penetration into the(More)
1. The effects of electrical activation of muscle nerves at strengths sufficient to activate group II afferents in contralateral hindlimb motoneurones have been investigated by intracellular recording from motoneurones in alpha-chloralose-anaesthetized cats in which the spinal cord was intact or transected at a low thoracic level. 2. A large proportion of(More)
The classically conditioned eyeblink response in the rabbit is one of the best-characterized behavioral models of associative learning. It is cerebellum dependent, with many studies indicating that the hemispheral part of Larsell's cerebellar cortical lobule VI (HVI) is critical for the acquisition and performance of learned responses. However, there remain(More)
To illuminate the action of non-invasive stimuli on the human cerebral cortex, responses of corticospinal axons and of plantar alpha-motor neurons following transcranial magnetic (TMS) and electrical stimulation (TES) were recorded in the lumbosacral cord in the anaesthetized macaque monkey. A round coil was used for TMS, and the anode was located at the(More)