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A chemical description of the action of phospholipase A2 (PLA2) can now be inferred with confidence from three high-resolution x-ray crystal structures. The first is the structure of the PLA2 from the venom of the Chinese cobra (Naja naja atra) in a complex with a phosphonate transition-state analogue. This enzyme is typical of a large, well-studied(More)
Troponin, a Ca2+-sensitive complex, regulates the motions of tropomyosin on the thin filaments in many muscles. It has three subunits, each with a different architecture and function: TnC binds Ca2+; TnI binds to actin and inhibits contraction; and TnT binds one complex to each tropomyosin molecule. The troponin complex has an elongated shape with TnC and(More)
The D0 experiment's data and job management system software, SAM, is an operational prototype of many of the concepts being developed for Grid computing. We explain how the components of SAM map into the Data Grid architecture. We discuss the future use of Grid components to either replace existing components of SAM or to extend its functionality and(More)
Histological images from the longitudinal section of four diseased coronary arteries were used, for the first time, to study the pulsatile blood flow distribution within the lumen of the arteries by means of computational fluid dynamics (CFD). Results indicate a strong dependence of the hemodynamics on the morphology of atherosclerotic lesion. Distinctive(More)
Phospholipase A2 (PLA2) participates in a wide range of cellular processes including inflammation and transmembrane signaling. A human nonpancreatic secretory PLA2 (hnps-PLA2) has been identified that is found in high concentrations in the synovial fluid of patients with rheumatoid arthritis and in the plasma of patients with septic shock. This enzyme is(More)
The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is(More)
The DØ experiment at Fermilab relies on a central Oracle database for storing all detector calibration information. Access to this data is needed by hundreds of physics applications distributed worldwide. In order to meet the demands of these applications from scarce resources, we have created a distributed system that isolates the user applications from(More)
One of the key components of any grid architecture is managing compute and storage resources and optimizing their utilization. SAM has implemented features that allow it to exercise a "fair share" and "prioritized" policy among many groups of users. The goals are as follows: 1) implement the experiments policies for resource usage by research group and by(More)
The open pit at the Lihir Gold Mine, Papua New Guinea is planned to ultimately reach more than 200 metres below sea level. Cooling and depressurisation of the geothermal resource associated with the gold mineralisation is an essential part of the mining operation. Eight deep, deviated geothermal wells were completed during 1999 to investigate geothermal(More)
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