Stephen Welch

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Progress in breeding higher-yielding crop plants would be greatly accelerated if the phenotypic consequences of making changes to the genetic makeup of an organism could be reliably predicted. Developing a predictive capacity that scales from genotype to phenotype is impeded by biological complexities associated with genetic controls, environmental effects(More)
The FireGrid project aims to harness the potential of advanced forms of computation to support the response to large-scale emergencies (with an initial focus on the response to fires in the built environment). Computational models of physical phenomena are developed, and then deployed and computed on High Performance Computing resources to infer incident(More)
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This paper provides a 'state of the art' review of research into the effects of high temperature on concrete and concrete structures, extending to a range of forms of construction, including novel developments. The nature of concrete-based structures means that they generally perform very well in fire. However, concrete is fundamentally a complex material(More)
FireGrid is a modern concept that aims to leverage a number of modern technologies to aid fire emergency response. In this paper we provide a brief introduction to the FireGrid project. A number of different technologies such as wireless sensor networks, grid-enabled High Performance Computing (HPC) implementation of fire models, and artificial intelligence(More)
A novel methodology for generalising CFD-based approaches for thermal analysis of protected steelwork in fire has been developed, known as GeniSTELA. This is a quasi-3D approach with computation of a "steel temperature field" parameter in each computational cell. The methodology accommodates both uncertainties in the input parameters and possible variants(More)
A review of research into the burning behaviour of large pool fires and fuel spill fires is presented. The features which distinguish such fires from smaller pool fires are mainly associated with the fire dynamics at low source Froude numbers and the radiative interaction with the fire source. In hydrocarbon fires, higher soot levels at increased diameters(More)
This paper provides a " State of the Art " review on current research into the effects of fire exposures upon concrete. The principal influences of high temperature in concrete are loss of compressive strength and spalling, the forcible ejection of material from a member. Though a lot of information has been gathered on both phenomena, there remains a need(More)
BACKGROUND This phase 1b study assessed the maximum tolerated dose (MTD), safety, and pharmacokinetics of motesanib (a small-molecule antagonist of VEGF receptors 1, 2, and 3; platelet-derived growth factor receptor; and Kit) administered once daily (QD) or twice daily (BID) in combination with erlotinib and gemcitabine in patients with solid tumors. (More)