Stephen Welch

Learn More
Progress in breeding higher-yielding crop plants would be greatly accelerated if the phenotypic consequences of making changes to the genetic makeup of an organism could be reliably predicted. Developing a predictive capacity that scales from genotype to phenotype is impeded by biological complexities associated with genetic controls, environmental effects(More)
FireGrid is a modern concept that aims to leverage a number of modern technologies to aid fire emergency response. In this paper we provide a brief introduction to the FireGrid project. A number of different technologies such as wireless sensor networks, grid-enabled High Performance Computing (HPC) implementation of fire models, and artificial intelligence(More)
BACKGROUND Fluoropyrimidine-based chemotherapy is considered standard treatment of advanced colorectal cancer. Recent studies indicate benefit to the addition of bevacizumab, a recombinant monoclonal antibody targeting vascular endothelial growth factor. METHODS Medline, EMBASE, Cochrane Library, and conference proceedings were searched to identify(More)
The FireGrid project aims to harness the potential of advanced forms of computation to support the response to large-scale emergencies (with an initial focus on the response to fires in the built environment). Computational models of physical phenomena are developed, and then deployed and computed on High Performance Computing resources to infer incident(More)
PURPOSE To determine the wait times and healthcare costs around the time of non-small cell lung cancer (NSCLC) diagnosis for a large, population-based cohort of patients. METHODS Data on baseline demographics, diagnostic and staging tests, timelines of investigations, and frequency of physician visits and hospital admissions were obtained from a(More)
Previous phase III studies raised concern about the safety of the combination of capecitabine and irinotecan in patients with metastatic colorectal cancer (mCRC). We conducted a single arm phase II study to evaluate the safety and efficacy of bevacizumab in combination with dose-reduced capecitabine and irinotecan in patients with previously untreated mCRC.(More)
The successes of targeted drugs with companion predictive biomarkers and the technological advances in gene sequencing have generated enthusiasm for evaluating personalized cancer medicine strategies using genomic profiling. We assessed the feasibility of incorporating real-time analysis of somatic mutations within exons of 19 genes into patient management.(More)
  • R Goel, E Chen, +7 authors A Oza
  • Journal of clinical oncology : official journal…
  • 2009
e13509 Background: E7389 (E) is a synthetic analogue of halichondrin B, an investigational tubulin-based antimitotic drug. Gemcitabine (G) is a nucleoside analogue clinically active in several human tumours. These two drugs exhibit synergistic cytotoxic effects against the H522 non-small cell lung cancer (NSCLC) xenografts. METHODS A phase I study of(More)
A novel methodology for generalising CFD-based approaches for thermal analysis of protected steelwork in fire has been developed, known as GeniSTELA. This is a quasi-3D approach with computation of a "steel temperature field" parameter in each computational cell. The methodology accommodates both uncertainties in the input parameters and possible variants(More)