Stephen W. Sorensen

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CONTEXT Although diabetes mellitus is one of the most prevalent and costly chronic diseases in the United States, no estimates have been published of individuals' average lifetime risk of developing diabetes. OBJECTIVE To estimate age-, sex-, and race/ethnicity-specific lifetime risk of diabetes in the cohort born in 2000 in the United States. DESIGN,(More)
BACKGROUND The Diabetes Prevention Program (DPP) demonstrated that interventions can delay or prevent the development of type 2 diabetes. OBJECTIVE To estimate the lifetime cost-utility of the DPP interventions. DESIGN Markov simulation model to estimate progression of disease, costs, and quality of life. DATA SOURCES The DPP and published reports. (More)
OBJECTIVE To estimate the cost-effectiveness of screening overweight and obese individuals for pre-diabetes and then modifying their lifestyle based on the Diabetes Prevention Program (DPP). RESEARCH DESIGN AND METHODS A Markov simulation model was used to estimate disease progression, costs, and quality of life. Cost-effectiveness was evaluated from a(More)
packa geepp/. Accessed January 12, 2011. 10. National AIDS Council Secretariat and the National Department of Health. 2007 Estimation Report. Port Moresby, PNG: National AIDS Council Secretariat and the National Department of Health; 2008. 11. PNG Demographic and Health Survey, 2006. National statistics office. Available at: http://(More)
BACKGROUND No randomized, controlled trial of screening for diabetes has been conducted. In the absence of direct evidence, cost-effectiveness models may provide guidance about preferred screening strategies. OBJECTIVE To estimate the incremental cost-effectiveness of 2 diabetes screening strategies: screening targeted to people with hypertension and(More)
OBJECTIVE The Diabetes Prevention Program (DPP) lifestyle intervention is a cost-effective strategy to prevent type 2 diabetes, but it is unclear how this intervention could be financed. We explored whether this intervention could be offered in a way that allows return on investment for private health insurers while remaining attractive for consumers,(More)
BACKGROUND Early diagnosis and treatment of HIV infection and suppression of viral load are potentially powerful interventions for reducing HIV incidence. A test-and-treat strategy may have long-term effects on the epidemic among urban men who have sex with men (MSM) in the United States and may achieve the 5-year goals of the 2010 National AIDS Strategy(More)
BACKGROUND Several interventions can be applied to prevent complications of type 2 diabetes. This article examines the optimal allocation of resources across 4 interventions to treat patients newly diagnosed with type 2 diabetes. The interventions are intensive glycemic control, intensified hypertension control, cholesterol reduction, and smoking cessation.(More)
The purpose of this study was to assess the validity of the CDC-RTI Diabetes CostEffectiveness Model by comparing rates of diabetes incidence and complications to existing published results. We performed 47 internal and external validation exercises comparing the model-simulated outcomes with the outcomes from 24 published trials. To simulate the outcomes(More)
In a series of three papers in the British Medical Journal (June 28, 2003), Wald et al. proposed that the Polypill can reduce the incidence of coronary heart disease by 88%, and stroke by 80%, if taken by all people aged > or = 55, as well as people of any age with existing cardiovascular disease or diabetes. We review the rationale and uniqueness behind(More)