Stephen W. Smye

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During saccadic motion the eyewall moves in a manner similar to a sinusoid or at least can be represented by a sine Fourier series. Motion of the vitreous is induced by the saccade and the vitreo-retinal interface is subjected to a time-dependent shear. This force may be a significant factor for retinal tearing in the neighbourhood of small retinal holes or(More)
The 2-pool urea kinetic model has been developed analytically and applied to the description of the observed increase in blood levels of urea following dialysis (urea rebound), assuming that the dialyser urea clearance K less than 0.4X where X is the urea mass transfer coefficient between the intracellular and extracellular pools (volumes V1, V2(More)
INTRODUCTION In CAPD patients serum albumin is frequently used as an index of nutritional status, although it is recognized that hypoalbuminaemia may be caused by many factors. We have further examined the relationship between serum albumin and nutrition. METHODS Nutritional status was assessed by biochemistry, anthropometry, mid-arm muscle circumference,(More)
Infertility affects one in six couples at some time in their lives, with 48% of these couples requiring assisted conception techniques in order to achieve a pregnancy. Whilst the overall clinical pregnancy rate per embryo transfer is 23%, this varies widely between clinics. The Human Fertilisation and Embryology Authority has attempted to analyse the(More)
With increasing life expectancies and the desire to maintain active lifestyles well into old age, the impact of the debilitating disease osteoarthritis (OA) and its burden on healthcare services is mounting. Emerging regenerative therapies could deliver significant advances in the effective treatment of OA but rely upon the ability to identify the initial(More)
Blood urea concentration is artificially low immediately following high-efficiency dialysis of duration T and will rise ('rebound') due to the continued diffusion of urea from the intracellular to the extracellular space. This leads to an overestimate of the efficiency of the dialysis given by KT/V (where V is the total distribution volume of urea and K is(More)
Four commercial whole-body impedance measuring systems (Holtain, RJL, Bodystat and EZcomp) were compared on two separate occasions for a group of normal subjects. The first set of readings in 21 subjects demonstrated a significant difference of approximately 6% between the Holtain measurement and the higher readings from the Bodystat or RJL systems. The(More)
This paper describes a method of effectively electroporating mammalian cell membranes with pulsed alternating-current (ac) electric fields at field strengths of 30-160 kV m(-1). Although many in vivo electroporation protocols entail applying square wave or monotonically decreasing pulses via needles or electrode plates, relatively few have explored the use(More)
The glomerular filtration rate (GFR) is used clinically to assess renal function. The most accurate estimation technique is tracer clearance where deterministic compartment pharmacokinetic models are most widely used. The aim of this study was to assess the viability of alternative pharmacokinetic models to describe tracer clearance, and in turn, measure(More)
AIM To investigate the relationship between serum albumin and extracellular fluid volume, as measured by multifrequency bioelectrical impedance, in stable patients treated by CAPD. METHOD Fifty-nine stable CAPD patients were assessed. Serum albumin (bromocresol green) and CRP, age, dialysate to plasma (D/P) creatinine ratio, normalized protein catabolic(More)