Stephen W. Smith

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OBJECTIVE To characterize the safety profile of tenofovir disoproxil fumarate (DF) for the treatment of HIV infection in adults over the first 4 years of use. METHODS A tenofovir DF expanded access program (EAP) was initiated in 2001; safety data were examined from this program and from the manufacturer's database, which contained reports of all(More)
Transducer design and phased array beam steering are developed for a volumetric ultrasound scanner that enables the 3-D visualization of dynamic structures in real time. The authors describe the design considerations and preliminary evaluation of a high-speed, online volumetric ultrasound imaging system that uses the principles of pulse-echo, phased array(More)
The National Opinion Research Center, led by a team of investigators at the University of Chicago, conducted more than 3,000 in-person interviews with a nationally representative sample of adults aged 57-85 years. Data collection included in-person questionnaire items, an extensive array of biomeasures, and a postinterview self-administered questionnaire.(More)
γ-Hydroxybutyrate (GHB) and its prodrugs are drugs of abuse that were also sold as "dietary supplements." Users present to emergency departments with overdose, impaired driving, withdrawal, and associated trauma. We compiled a series of GHB-associated deaths to elucidate lethal risks, GHB concentrations, cointoxicants, products, uses, and medical(More)
For pt.I see ibid., vol.38, no.2, p.100-8 (1991). The authors describe the design, application, and evaluation of parallel processing to the high-speed volumetric ultrasound imaging system. The scanner produces images analogous to an optical camera or the human eye and supplies more information than conventional sonograms. Potential medical applications(More)
BACKGROUND Cardiac troponin is the preferred biomarker for detecting acute myocardial injury and infarction (MI). We studied whether multiple biomarkers of numerous pathophysiological pathways would increase the diagnostic accuracy for detecting MI. METHODS Seven biomarkers [myeloperoxidase, soluble CD40 ligand, placental growth factor, matrix(More)
BACKGROUND We determined the diagnostic accuracy of the Advia Centaur TnI-Ultra assay for detecting myocardial infarction (MI) and assessing risk of adverse events in patients presenting with ischemic symptoms suggestive of acute coronary syndrome. METHODS We measured cardiac troponin I (cTnI) on admission and 6-24 h after admission (follow-up) in plasma(More)
BACKGROUND 1,4-Butanediol is an industrial solvent that, when ingested, is converted to gamma-hydroxybutyrate, a drug of abuse with depressant effects, primarily on the central nervous system. After reports of toxic effects of gamma-hydroxybutyrate and its resultant regulation by the federal government, 1,4-butanediol and gamma-butyrolactone, another(More)
OBJECTIVES We investigated these questions: Does formal team training improve team behaviors in the trauma resuscitation bay? If yes, then does improved teamwork lead to more efficiency in the trauma bay and/or improved clinical outcomes? DESIGN This intervention study used a pretraining/posttraining design. The intervention was TeamSTEPPS augmented by(More)