Stephen R Priebe

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Two pyrazolotetrazine derivatives were synthesized as the analogous prodrugs of the light-sensitive antineoplastic agents dacarbazine and BIC. Both the pyrazole derivatives are stable under ordinary light illumination. Biological evaluation of these pyrazoles revealed that the compound containing a 2-chloroethyl function (6a) demonstrated good(More)
Current indoor wireless communication systems are shifting from classical microwave bands towards mm wave frequencies, whereas here the 60 GHz band is of special interest. Future systems are expected to work at even higher carrier frequencies in the sub-mm band beyond 300 GHz. In indoor wave propagation channels of such systems, diffraction occurs at a(More)
Exposure of clinafloxacin to light results in photochemical degradation. The polar and nonpolar photodegradation products were profiled by HPLC using two sets of conditions. Clinafloxacin was subjected to severe light exposure conditions to obtain elevated levels of the photodegradation products for characterization. The structures of eight new degradation(More)
A series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1,8-naphthyridine-3-carboxylic acids, 1-cyclopropyl-6,8-difluoro-3-quinolinecarboxylic acids, 1-cyclopropyl-6-fluoro-3-quinolinecarboxylic acids, and 5-amino-1-cyclopropyl-6,8-difluoro-3-quinolinecarboxylic acids have been prepared and evaluated for comparative(More)
Seven degradation products observed in formulated pregabalin have been characterized. These compounds result from Maillard reactions and Amadori rearrangements. Heating pregabalin in the presence of lactose formed significant quantities of these degradation products. The seven compounds corresponding to the observed degradation products were isolated by(More)
Achiral and chiral HPLC methods were developed for clinafloxacin, a quinolone antimicrobial agent. For achiral assay, analytes were isolated from plasma by precipitating plasma proteins. Separation was achieved on a C18 column using an isocratic eluent of ion pairing solution-acetonitrile (80:20, v/v) at 1.0 ml/min with UV detection at 340 nm. The ion(More)
The development and application of a post-column reaction detection system for organophosphorus compounds based upon their photodegradation to ortho-phosphate followed by the formation of reduced heteropolymolybdate is reported. Photodegradation occurs in a fused-silica tube coiled about a 450-W xenon lamp in the presence of ammonium peroxydisulfate.(More)