Stephen R Cooke

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Dialysis disequilibrium syndrome is a rare neurological manifestation of intermittent hemodialysis. Urea removal occurs more slowly across the blood-brain barrier than from the plasma, generating an osmotic gradient that promotes water movement into the brain and cerebral edema. The authors report the development of dialysis disequilibrium syndrome in a(More)
BACKGROUND Since the condition was first described in 1965, the syndrome of normal pressure hydrocephalus (NPH) has conventionally been managed by placement of a cerebrospinal fluid (CSF) shunt. OBJECTIVES To determine the effectiveness of shunting procedures in promoting stability or improvement in the neurological symptoms and signs of NPH. SEARCH(More)
The venometer is a nurse- or technician-operated machine that uses automated strain gauge plethysmography to detect deep vein thrombosis (DVT). We compared the venometer with contrast venography to determine its accuracy, and also used it to triage patients between admission with subsequent anticoagulation and out-patient investigation without(More)
BACKGROUND & AIMS Little is known about energy requirements in brain injured (TBI) patients, despite evidence suggesting adequate nutritional support can improve clinical outcomes. The study aim was to compare predicted energy requirements with measured resting energy expenditure (REE) values, in patients recovering from TBI. METHODS Indirect calorimetry(More)
Three cases are present to demonstrate the usefulness of oral or rectal technetium-99m preparations in locating the stomach and bowel in relation to abnormal accumulation of gallium-67 within the abdomen. In this way, the concentration of gallium in an abscess or a tumor may be distinguished from its physiologic excretion into the bowel.
Urinary 8-oxo-7,8-dihydro-2‟-deoxyguanosine (8-oxodGuo) is widely used as a marker of oxidative stress. Herein we report the comparison of two, distinct chromatographic assays, with ELISA. Chromatographic assays displayed good agreement (r = 0.89, p < 0.0001), whereas there was markedly worse, albeit still significant, agreement with ELISA (HPLC-GC/MS:(More)
BACKGROUND We describe an outbreak of Clostridium difficile infection (CDI) with ribotype 053, a possible hypervirulent strain that causes outbreaks, in a neurosurgical unit. OUTBREAK INVESTIGATION The outbreak was investigated by creating a timeline of all toxin positive patients with root cause analysis, supplemented with ribotyping results, hand(More)
The aim of this study was to assess contemporary management of slipped capital femoral epiphysis (SCFE) by surveying members of the British Society of Children's Orthopaedic Surgery (BSCOS). A questionnaire with five case vignettes was used. Two questions examined the timing of surgery for an acute unstable SCFE in a child presenting at 6 and 48 h after(More)