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One of the reasons large-scale software development is difficult is the number of dependencies that software engineers face. These dependencies create a need for communication and coordination that requires continuous effort by developers. Empirical studies, including our own, suggest that technical dependencies among software components create social(More)
Key Findings We introduce and explicate a novel development paradigm for distributed software engineering development tools, Continuous Coordination. Continuous Coordination constitutes a paradigm for collaborative systems, which combines elements of traditionally formal, process-oriented approaches with those of the more informal, awareness-based(More)
One of the reasons why large-scale software development is difficult is the number of dependencies that software engineers need to face; e.g., dependencies among the software components and among the development tasks. These dependencies create a need for communication and coordination that requires continuous effort by software developers. Empirical(More)
Steered Molecular Dynamics (SMD) has been seen to provide the potential of mean force (PMF) along a peptide unfolding pathway effectively but at significant computational cost, particularly in all-atom solvents. Adaptive steered molecular dynamics (ASMD) has been seen to provide a significant computational advantage by limiting the spread of the(More)
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder for which the biochemical defect is as yet unknown. Recently, two cloned segments of human X-chromosome DNA have been described which detect structural alterations within or near the genetic locus responsible for the disorder. Both of these cloned segments were described as tightly(More)
We determined the amino acid sequence of the actin monomer binding/actin filament severing protein actophorin from Acanthamoeba castellanii by automated Edman degradation of peptide fragments and by sequencing of full-length cDNA. Actophorin consists of 138 amino acids (calculated molecular weight of 15,543) and shares a high degree of sequence similarity(More)
A series of shape-modified flexible nucleosides ('fleximers', 1, 2, and 3) was modeled, synthesized and subsequently assayed against S-adenosyl-L-homocysteine hydrolase (SAHase). No inhibitory activity was observed for the adenosine fleximer, which served as a substrate, but moderate inhibitory activity was exhibited by the guanosine fleximers. This is the(More)
A new class of shape-modified nucleosides is introduced. These novel "fleximers" feature the purine ring systems of adenosine, inosine, and guanosine split into their individual imidazole and pyrimidine components (as in 1-3). This structural modification serves to introduce flexibility into the nucleoside while still retaining the elements essential for(More)