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Insufficiency of the transcriptional regulator GTF2IRD1 has become a strong potential explanation for some of the major characteristic features of the neurodevelopmental disorder Williams-Beuren syndrome (WBS). Genotype/phenotype correlations in humans indicate that the hemizygous loss of the GTF2IRD1 gene and an adjacent paralogue, GTF2I, play crucial(More)
BACKGROUND Cognitive-behavioural therapy (CBT) improves persistent psychotic symptoms. AIMS To test the effectiveness of added CBT in accelerating remission from acute psychotic symptoms in early schizophrenia. METHOD A 5-week CBT programme plus routine care was compared with supportive counselling plus routine care and routine care alone in a(More)
A research paradigm, including an AB1AB2 single-subject design was developed and used in conjunction with an adult-child interaction analysis methodology to evaluate the effectiveness of a behavioral treatment approach to a feeding problem in a 2 1/2-year-old male. The results indicate that after nine treatment sessions, the child's diet was appropriate and(More)
OBJECTIVE To assess the cost effectiveness of primary angioplasty, compared with medical management with thrombolytic drugs, to achieve reperfusion after acute myocardial infarction (AMI) from the perspective of the UK NHS. DESIGN Bayesian evidence synthesis and decision analytic model. METHODS A systematic review was conducted and Bayesian statistical(More)
BACKGROUND Depression is the most common mental disorder in community settings and a major cause of disability across the world. The objective of treatment is to achieve remission or at least adequate control of depressive symptoms; however, even after successful treatment, the risk of relapse after remission is significant. Although the effectiveness of(More)
There is accumulating evidence that the mammalian Y chromosome, in addition to its testis-determining function, may have other male limited functions, particularly in spermatogenesis. We have previously shown that the short arm of the mouse Y carries information needed for spermatogonial proliferation. This information, together with the testis-determining(More)
BACKGROUND For patients who continue to have seizures despite ongoing treatment, surgical resection of the epileptic focus may be considered, and can result in seizure-freedom. Currently, non-invasive tests provide information to inform the scope and positioning of invasive electroencephalography (EEG) electrodes. However, these technologies could replace(More)
BACKGROUND Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease. METHODS AND FINDINGS We searched MEDLINE (1966 to 2009) and(More)
OBJECTIVE To evaluate the cost effectiveness of routine screening for postnatal depression in primary care. DESIGN Cost effectiveness analysis with a decision model of alternative methods of screening for depression, including standardised postnatal depression and generic depression instruments. The performance of screening instruments was derived from a(More)
BACKGROUND Longer-term follow-up of patients with borderline personality disorder have found favourable clinical outcomes, with long-term reduction in symptoms and diagnosis. AIMS We examined the 6-year outcome of patients with borderline personality disorder who were randomised to 1 year of cognitive-behavioural therapy for personality disorders (CBT-PD)(More)