Stephen P Rogers

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BACKGROUND In 2008, the US Food and Drug Administration (FDA) issued a Guidance for Industry statement formally recognizing (during drug development) the conjoined nature of type 2 diabetes (T2D) and cardiovascular disease (CVD), which has precipitated an urgent need for panels of markers (and means of analysis) that are able to differentiate subtypes of(More)
BACKGROUND Low hemoglobin concentration (Hb) and low mean arterial blood pressure (MAP) impact outcomes in critically ill patients. We utilized an experimental model of "normotensive" vs. "hypotensive" acute hemodilutional anemia to test whether optimal tissue perfusion is dependent on both Hb and MAP during acute blood loss and fluid resuscitation, and to(More)
Obesity has emerged as a major co-morbidity in patients with psoriasis. In a case control study we found that patients with psoriasis had significantly higher body mass indices (BMI) compared to controls (p = 0.004). Increased adiposity and weight gain were strong risk factors for the development of psoriasis in the Nurses Health study 1. Multivariate(More)
Purpose We evaluated the clinical efficacy of 0.005% PbXA41, a new phenyl-substituted prostaglandin Fza-isopropyl ester analogue, in primary open angle glaucoma (POAG) and ocular hypertension (OH) patients. We also investigated the effect of PhXA41 on diurnal and noctomal IOP changes in normal volunteers. Methods 1) A multicentral randomized, double-masked(More)
Cell suspension from the spleen of rabbits immunised with monkey brain gave rise to epileptic discharges in the monkey when injected intracortically, except in the case of one injection from a rabbit not recently given a booster treatment. In contrast, cell suspensions from the spleen of unimmunised rabbits, or of a rabbit immunised with a non-brain(More)
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