Stephen Mitchell

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AIMS Mixed treatment comparisons (MTC) were performed to assess the relative efficacy and tolerability of the main anti-arrhythmic drugs used for the treatment of atrial fibrillation (AF)/flutter. METHODS AND RESULTS Electronic databases were systematically searched to identify randomized controlled trials (RCTs) examining amiodarone, dronedarone,(More)
Plants alter their environment in a number of ways. With correct management, plant communities can positively impact soil degradation processes such as surface erosion and shallow landslides. However, there are major gaps in our understanding of physical and ecological processes on hillslopes, and the application of research to restoration and engineering(More)
More precise prognostic models are needed for prediction of survival in patients with primary sclerosing cholangitis (PSC), particularly for the selection of candidates for liver transplantation. The aim of this study was to develop a time-dependent prognostic model for the calculation of updated short-term survival probability in PSC. Consecutive clinical(More)
Variants of the human melanoma cell line LT5.1 were selected for high and low expression of the \1, 90,000 CD44 glycoprotein by using the Hermes-3 monoclonal antibody combined with fluorescence-activated cell sorting. Cells were single cell cloned and clones of CD44 highexpressing and CD44 low-expressing phenotype were isolated. The var iants, which(More)
BACKGROUND Flexible ureterorenoscopy is a minimally invasive procedure that is rapidly gaining popularity as a treatment for patients with upper urinary tract lithiasis. One of the main drawbacks is the limited visualization imposed by fiberoptic technology in an endoscope, often only 7 to 8F and the fragility of fiber-based optics in a flexible endoscope.(More)
Exposure to ionizing radiation can increase the risk of cancer, which is often characterized by genomic instability. In environmental exposures to high-LET radiation (e.g. 222Ra), it is unlikely that many cells will be traversed or that any cell will be traversed by more than one alpha particle, resulting in an in vivo bystander situation, potentially(More)
The management of upper urinary tract urothelial carcinoma (UUT-UC) is controversial. Radical nephroureterectomy is a major undertaking and has obvious shortcomings in the presence of renal impairment and solitary kidneys, whereas endoscopic management can be associated with a risk of disease progression. There is a pressing need for reliable predictive(More)
A non-parametric procedure for Cattell's scree test is proposed, using the bootstrap method. Bentler and Yuan developed parametric tests for the linear trend of scree eigenvalues in principal component analysis. The proposed method is for cases where parametric assumptions are not realistic. We define the break in the scree trend in several ways, based on(More)