Stephen Macfarlane

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This study investigated age changes in risk perception and unrealistic optimism. Teenagers (n = 376) and parents (n = 160) evaluated the risk of experimental, occasional, and regular involvement in 14 health-related activities (e.g., getting drunk). Respondents also evaluated their comparative changes of encountering the leading causes of morbidity and(More)
BACKGROUND Atypical antipsychotics are commonly used in the management of schizophrenia in late life with evidence suggesting they induce lower rates of motor disturbance, but have similar efficacy to conventional antipsychotics. Trials in the elderly have been either retrospective, small, of short duration or of a single-arm design. AIMS To demonstrate(More)
OBJECTIVES Systematic reviews are one of the major building blocks of evidence-based medicine. This overview is an introduction to conducting systematic reviews and meta-analyses. CONCLUSIONS Systematic reviews and meta-analyses of randomised controlled trials (RCTs) represent the most robust form of design in the hierarchy of research evidence. In(More)
Most plant viruses rely on vector organisms for their plant-to-plant spread. Although there are many different natural vectors, few plant virus-vector systems have been well studied. This review describes our current understanding of virus transmission by aphids, thrips, whiteflies, leafhoppers, planthoppers, treehoppers, mites, nematodes, and zoosporic(More)
BACKGROUND We aimed to assess why carers seek participation for their relatives in clinical trials of Alzheimer's disease (AD) medications, and to assess carer impressions of the value of trial participation. METHOD A retrospective questionnaire was sent to 31 carers of participants in clinical trials for AD conducted at the Mental Health Research(More)
BACKGROUND Following an earlier study in which elderly patients with schizophrenia had their typical antipsychotic medication changed to olanzapine or risperidone, the 61 patients were followed for up to a further six months to see if either treatment was superior in terms of efficacy or side effects. AIMS To determine whether either olanzapine or(More)
BACKGROUND We explored carer motivation for seeking participation for a relative in an Alzheimer's disease (AD) clinical drug trial, to assess impressions of the value of trial participation. We also surveyed the carers of patients who did not meet study entry screening criteria to see if our conduct of the screening visit was acceptable and ethical. (More)
OBJECTIVE To describe the style of psychotherapy portrayed in the film "Antwone Fisher". The rationale for this examination is that prospective patients often have little idea about what the process of psychotherapy may involve; depictions of therapy in popular films and on television serve to "prime" our patients' expectations in this regard. CONCLUSIONS(More)
OBJECTIVE Although the evidence base for the use of antipsychotics in older people with schizophrenia is generally of low quality, it tends to support the use of atypical antipsychotics. Only limited information regarding longer term adherence to these apparently more effective drugs is available. The aim of this study was to determine predictors of(More)