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Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported. Here we report the identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic(More)
Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of(More)
Introduction: Residual neuromuscular blockade contributes to postoperative morbidity and mortality, and is more common with long-acting non-depolarising muscle relaxants (NDMRs) such as pancuronium [1]. This phenomenon may be a common occurrence in 'fast-track' managed cardiac patients administered long-acting NDMRs. We examine the usage of NDMRs in cardiac(More)
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