Stephen Kum Jew

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Patients with SALS and non-SOD1 mutant familial ALS (FALS) have cytoplasmic aggregates of TAR DNA binding protein 43 (TDP-43) in motor neurons and glia (Tan et al., Acta Neuropathol 113: 535, 2007). This suggests that TDP43 has a central role in the pathogenesis of ALS. Reports of mutations in the gene encoding TDP-43, TARDBP, in patients with either FALS(More)
The posterior cingulate cortex (PCC), a key component of the limbic system, has been implicated in the pathology of schizophrenia because of its sensitivity to NMDA receptor antagonists. Recent studies have shown that the PCC is dysfunctional in schizophrenia, and it is now suspected to be critically involved in the pathogenesis of schizophrenia. Studies(More)
Exposure to environmental mercury has been proposed to play a part in autism. Mercury is selectively taken up by the human locus ceruleus, a region of the brain that has been implicated in autism. We therefore looked for the presence of mercury in the locus ceruleus of people who had autism, using the histochemical technique of autometallography which can(More)
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