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  • Paula J. Kaplan-Lefko, Jonathan D. Graves, +16 authors Brian C. Gliniak
  • Biology, Medicine
  • Cancer biology & therapy
  • 2010 (First Published: 15 April 2010)
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptors 4 and 5 (DR4, DR5) to transduce apoptotic signals. Conatumumab (AMG 655) is an investigational, fully humanContinue Reading
  • Gloria Juan, Tammy L. Bush, +9 authors Marc Payton
  • Biology, Medicine
  • Journal of Translational Medicine
  • 2014 (First Published: 1 December 2014)
  • BackgroundThe Aurora family of serine-threonine kinases are essential regulators of cell division in mammalian cells. Aurora-A and -B expression and kinase activity is elevated in a variety of humanContinue Reading
  • Beth Ziegler, Gloria Juan, +11 authors Tammy L. Bush
  • Medicine
  • 2010 (First Published: 15 April 2010)
  • Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Background: The aurora family of serine-threonine kinases (Aurora-A, -B, -C) regulate cell-cycle progression inContinue Reading
  • Peter J. Rosen, A Craig Lockhart, +12 authors Peter Nan-shong Lee
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2013 (First Published: 20 February 2013)
  • 41 Background: AMG 208 is a small molecule MET inhibitor that suppresses proliferation and induces apoptosis in human tumor xenografts. This first-in-human study evaluated the safety, tolerability,Continue Reading