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- Surya M. Nauli, Francis J. Alenghat, +9 authors Jing Zhou
- Nature Genetics
- 2003
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (encoding polaris).… (More)
- Arthur D. Conigrave, Stephen J. Quinn, Edward Meigs Brown
- Proceedings of the National Academy of Sciences…
- 2000
The extracellular calcium (Ca(2+)(o))-sensing receptor (CaR) recognizes and responds to (i.e., "senses") Ca(2+)(o) as its principal physiological ligand. In the present studies, we document that the… (More)
- Stephen J. Quinn, Mei Bai, Edward Meigs Brown
- The Journal of biological chemistry
- 2004
The calcium-sensing receptor (CaR) is activated by small changes in the ionic extracellular calcium concentration (Ca(o)) within the physiological range, allowing the parathyroid gland to regulate… (More)
- Stephen J. Quinn, Gordon H. Williams
- Annual review of physiology
- 1988
Regulation of aldosterone secretion is complex both in terms of the number of secretagogues that can influence its biosynthesis and the number of second messengers utilized by these secretagogues… (More)
- Simon H. S. Pearce, Mingdong Bai, Stephen J. Quinn, Olga Kifor, Edward Meigs Brown, Rajesh V Thakker
- The Journal of clinical investigation
- 1996
The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that plays a key role in extracellular calcium ion homeostasis. We have engineered 11 CaR mutants that have been described in the… (More)
- Naibedya Chattopadhyay, Stephen J. Quinn, Olga Kifor, Chianping Ye, Edward Meigs Brown
- Biochemical pharmacology
- 2007
Strontium ranelate has several beneficial effects on bone and reduces the risk of vertebral and hip fractures in women with postmenopausal osteoporosis. We investigated whether Sr(2+) acts via a cell… (More)
- Mei Bai, Shephali Trivedi, Coldharbour Lane, Yong-ping Yang, Stephen J. Quinn, Edward Meigs Brown
- The Journal of biological chemistry
- 1998
Previous studies in parathyroid cells, which express the G protein-coupled, extracellular calcium-sensing receptor (CaR), showed that activation of protein kinase C (PKC) blunts high extracellular… (More)
- Mei Bai, Stephen J. Quinn, +6 authors Edward Meigs Brown
- The Journal of biological chemistry
- 1996
Nearly 30 mutations have been identified to date in the coding region of the extracellular calcium-sensing receptor (CaR) that are associated with inherited human hypo- and hypercalcemic disorders.… (More)
- Zaixiang Zhang, Shangjin Sun, Stephen J. Quinn, Edward Meigs Brown, Mei Bai
- The Journal of biological chemistry
- 2001
Recent studies have shown that the G protein-coupled, extracellular calcium ([Ca(2+)](o))-sensing receptor (CaR) forms disulfide-linked dimers through cysteine residues within its extracellular… (More)
- Stephen J. Quinn, Chian Ping Ye, +4 authors E Brown
- The American journal of physiology
- 1997
The Ca2+-sensing receptor (CaR) is activated at physiological levels of external Ca2+ (Ca(o)) but is expressed in a number of tissues that do not have well-established roles in the control of Ca(o),… (More)