Learn More
Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early(More)
The term 'transposition' describes how, during vertebrate evolution, anatomical structures have shifted up or down the axial series of segments. For example, the neck/thorax junction and the position of the forelimb in the chicken have shifted posteriorly, relative to mouse, by a distance of seven somites or vertebrae. By examining the expression boundaries(More)
We showed earlier (Gaunt, Miller, Powell & Duboule, 1986) that the mouse homoeobox gene Hox-1.5 is expressed in posterior ectoderm and mesoderm of 7 1/2- and 7 3/4-day embryos, and in the 9 1/2-day nervous system posterior to a discrete boundary within the hindbrain. In further in situ hybridization experiments, it is now shown that restriction of Hox-1.5(More)
Temporal colinearity describes a correspondence between the spatial ordering of Hox genes within their clusters (in the direction 3' to 5') and the time of their first expression (earlier to later) during embryonic development (Izpisúa-Belmonte et al. [1991] EMBO J. 10:2279-2289). It suggests that activation of each Hox gene might be controlled in some way(More)
A putative mouse homeobox gene (Hox-3.4) was previously identified 4kb downstream of the Hox-3.3 (Hox-6.1)* gene (Sharpe et al. 1988). We have now sequenced the Hox-3.4 homeobox region. The predicted amino acid sequence shows highest degree of homology in the mouse with Hox-1.3 and -2.1. This, together with similarities in the genomic organisation around(More)
Transposition of anatomical structures along the anteroposterior axis has been a commonly used mechanism for changing body proportions during the course of evolutionary time. Earlier work (Gaunt, S.J., 1994. Conservation in the Hox code during morphological evolution. Int. J. Dev. Biol. 38, 549-552; Burke, A.C., Nelson, C.E., Morgan, B.A., Tabin, C., 1995.(More)
Pattern formation in animal development requires that genes be expressed differentially according to position in the sheets of cells that make up the early embryo. The homoeobox-containing genes of Drosophila are control genes active both in the establishment of a segmentation pattern and in the specification of segment identity. In situ hybridization(More)
Expression patterns of Antennapedia-like homeogenes in the mouse embryo show many similarities o those of their homologues in Drosophila. It is argued here that homeogenes may regulate development of the body plan in mouse by mechanisms similar to those used in Drosophila. In particular, they may differentially specify positional address of cell groups(More)
The vertebrate caudal proteins, being upstream regulators of the Hox genes, play a role in establishment of the body plan. We describe analysis of two orthologous caudal genes (chick cdx-A and mouse cdx-1) by use of lacZ reporters expressed in transgenic mouse embryos. The expression patterns show many similarities to the expression of endogenous mouse(More)