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Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early(More)
We have isolated a murine homeobox-containing gene, Hox-5.1, by virtue of its relatedness to the Hox-1.4 gene. In situ hybridization to metaphase spreads mapped Hox-5.1 to band D of mouse chromosome 2. Sequence comparisons indicate that Hox-5.1 is the murine homolog of the human C13 homeobox-containing gene. Hox-5.1 also bears significant similarity to the(More)
Modifiers of position-effect-variegation in Drosophila encode proteins that are thought to modify chromatin, rendering it heritably changed in its expressibility. In an attempt to identify similar modifier genes in other species we have utilized a known sequence homology, termed chromo box, between a suppressor of position-effect-variegation,(More)
We showed earlier (Gaunt, Miller, Powell & Duboule, 1986) that the mouse homoeobox gene Hox-1.5 is expressed in posterior ectoderm and mesoderm of 7 1/2- and 7 3/4-day embryos, and in the 9 1/2-day nervous system posterior to a discrete boundary within the hindbrain. In further in situ hybridization experiments, it is now shown that restriction of Hox-1.5(More)
  • S J Gaunt
  • 2000
The term 'transposition' describes how, during vertebrate evolution, anatomical structures have shifted up or down the axial series of segments. For example, the neck/thorax junction and the position of the forelimb in the chicken have shifted posteriorly, relative to mouse, by a distance of seven somites or vertebrae. By examining the expression boundaries(More)
By use of in situ hybridization experiments, the mouse homeobox genes Hox-3.1 and Hox-1.5 are compared in the temporal and spatial patterns of their embryonic transcripts. Transcripts of both genes are first detected at about 7 1/2 days, although the appearance of Hox-3.1 transcripts apparently follows Hox-1.5 after a small delay. Hox-3.1 and Hox-1.5(More)
In Drosophila, the trithorax-group and the Polycomb-group genes are necessary to maintain the expression of the homeobox genes in the appropriate segments. Loss-of-function mutations in those groups of genes lead to misexpression of the homeotic genes resulting in segmental homeotic transformations. Recently, mouse homologues of the Polycomb-group genes(More)
  • S J Gaunt
  • 1994
The expression domains in paraxial mesoderm of the chicken embryo are described for Hoxb-3, a-4 and c-6 genes, and these are compared with published expression data for the corresponding genes in the mouse. In both species, it is found that the anterior limits of Hoxb-3 and a-4 expression lie in the upper cervical region, and the anterior limits of Hoxc-6(More)
After an earlier, transient phase of expression in the developing primitive streak of 6.4- to 6.8-day mouse embryos, the homeobox gene goosecoid is now shown to be expressed in a later phase of mouse development, from 10.5 days onwards. The later, spatially restricted domains of goosecoid expression are detected in the head, limbs and ventrolateral body(More)
Temporal colinearity describes a correspondence between the spatial ordering of Hox genes within their clusters (in the direction 3' to 5') and the time of their first expression (earlier to later) during embryonic development (Izpisúa-Belmonte et al. [1991] EMBO J. 10:2279-2289). It suggests that activation of each Hox gene might be controlled in some way(More)