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  • David Chipayo Gonzales, Stephen I. Rennard, +7 authors Karen R. Reeves
  • Medicine
  • 2006 (First Publication: 5 July 2006)
  • ContextThe α4β2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and maintaining smoking behavior. Varenicline, a novel α4β2 nAChR partial agonist, may beContinue Reading
  • Sreekumar G Pillai, Dongliang Ge, +15 authors David B. Goldstein
  • Biology, Medicine
  • PLoS genetics
  • 2009 (First Publication: 1 March 2009)
  • There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin,Continue Reading
  • Mitchell A. Nides, Cheryl A. Oncken, +4 authors Karen R. Reeves
  • Medicine
  • Archives of internal medicine
  • 2006 (First Publication: 14 August 2006)
  • BACKGROUND Currently available smoking cessation therapies have limited success rates. Varenicline tartrate is a novel, selective nicotinic receptor partial agonist developed specifically for smokingContinue Reading