Stephen Hammel

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The use of hepatocyte cultures is well established for the study of drug-drug interactions. However, the major hindrance for the use of human hepatocyte cultures is that human hepatocytes are only occasionally available. This problem could be overcome by cryopreservation. Although cryopreserved hepatocytes have been recommended for short term applications(More)
In this report, we address practical issues associated with tracking a single non-manoeuvering target using bearings-only data. In particular, we investigate the performance of various tracking algorithms and techniques by processing real trial data obtained from a field of sonobuoys. Difficulties using conventional modelling assumptions are illustrated.(More)
Mating between different species produces hybrids that are usually asexual and stuck as diploids, but can also lead to the formation of new species. Here, we report the genome sequences of 27 isolates of the pathogenic yeast Candida orthopsilosis. We find that most isolates are diploid hybrids, products of mating between two unknown parental species (A and(More)
The ability to extract, identify and annotate large amounts of biological data is a key feature of the "omics" era, and has led to an explosion in the amount of data available. One pivotal advance is the use of Next-Generation Sequencing (NGS) techniques such as RNA-sequencing (RNA-seq). RNA-seq uses data from millions of small mRNA transcripts or "reads"(More)
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