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High-level, or holistic, scene understanding involves reasoning about objects, regions, and the 3D relationships between them. This requires a representation above the level of pixels that can be endowed with high-level attributes such as class of object/region, its orientation, and (rough 3D) location within the scene. Towards this goal, we propose a(More)
Multi-class image segmentation has made significant advances in recent years through the combination of local and global features. One important type of global feature is that of inter-class spatial relationships. For example, identifying " tree " pixels indicates that pixels above and to the sides are more likely to be " sky " whereas pixels below are more(More)
The firefly luciferase protein contains a peroxisomal targeting signal at its extreme COOH terminus (Gould et al., 1987). Site-directed mutagenesis of the luciferase gene reveals that this peroxisomal targeting signal consists of the COOH-terminal three amino acids of the protein, serine-lysine-leucine. When this tripeptide is appended to the COOH terminus(More)
We consider the problem of estimating the depth of each pixel in a scene from a single monocular image. Unlike traditional approaches [18, 19], which attempt to map from appearance features to depth directly, we first perform a semantic segmentation of the scene and use the semantic labels to guide the 3D reconstruction. This approach provides several(More)
We address the problem of understanding an indoor scene from a single image in terms of recovering the room geometry (floor, ceiling, and walls) and furniture layout. A major challenge of this task arises from the fact that most indoor scenes are cluttered by furniture and decorations, whose appearances vary drastically across scenes, thus can hardly be(More)
Gaussian Markov random fields (GMRFs) are useful in a broad range of applications. In this paper we tackle the problem of learning a sparse GMRF in a high-dimensional space. Our approach uses the ℓ 1-norm as a regularization on the inverse covariance matrix. We utilize a novel projected gradient method, which is faster than previous methods in practice and(More)
PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal membrane proteins (PMPs). PEX19 binds these PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisome membrane, indicating that there may be a PEX19 docking factor in the peroxisome membrane. Here we show that PEX3 is required for(More)
Peroxisomes are components of virtually all eukaryotic cells. While much is known about peroxisomal matrix protein import, our understanding of how peroxisomal membrane proteins (PMPs) are targeted and inserted into the peroxisome membrane is extremely limited. Here, we show that PEX19 binds a broad spectrum of PMPs, displays saturable PMP binding, and(More)
Object detection and multi-class image segmentation are two closely related tasks that can be greatly improved when solved jointly by feeding information from one task to the other [10, 11]. However, current state-of-the-art models use a separate representation for each task making joint inference clumsy and leaving the classification of many parts of the(More)
Approximate MAP inference in graphical models is an important and challenging problem for many domains including computer vision , computational biology and natural language understanding. Current state-of-the-art approaches employ convex relaxations of these problems as surrogate objectives, but only provide weak running time guarantees. In this paper, we(More)