Stephen G. O’Brien

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Since the early 1980s, virtually every African country has received large amounts of aid aimed at stimulating policy reform. The results have varied enormously. Ghana and Uganda were successful reformers that grew rapidly and reduced poverty. Cote d’Ivoire and Ethiopia have shown significant reform in recent years, but it remains to be seen if this is(More)
This paper presents a new approach to higher dimensional segmentation. We present an extended Active Shape Model (ASM) formulation for the segmentation of multi-contour anatomical structures. We employ coupling and weighting schemes to improve the robustness of ASM segmentation. 3D segmentation is achieved through propagation of a 2D ASM using a learned(More)
1Medizinische Fakultaet Mannheim, University of Heidelberg, Mannheim, Germany; 2Oregon Health and Science University Cancer Institute, Portland; 3Memorial Sloan Kettering Cancer Center, New York, NY; 4Centre Hospitalier Universitaire (CHU) La La Milétri, Poitiers, France; 5Karmanos Cancer Institute, Detroit, MI; 6Department of Leukemia, The University of(More)
1M. D. Anderson Cancer Center, Houston, TX; 2Universitaetsklinikum Duesseldorf, Duesseldorf, Germany; 3H. Lee Moffitt Cancer Center, Tampa, FL; 4Azienda Policlinico Umberto I–Universita La Sapienza, Rome, Italy; 5S. Orsola–Malpighi University Hospital, University of Bologna, Bologna, Italy; 6Vrije University (VU) Medisch Centrum, Amsterdam, the Netherlands;(More)
Imatinib at 400 mg daily is standard treatment for chronic myeloid leukemia in chronic phase. We here describe the correlation of imatinib trough plasma concentrations (Cmins) with clinical responses, event-free survival (EFS), and adverse events (AEs). Trough level plasma samples were obtained on day 29 (steady state, n 351). Plasma concentrations of(More)
1Department of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia; 2Abt Hämatologie und internistische Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany; 3Molecular Pathology, SA Pathology, Adelaide, Australia and School of Medicine, University of Adelaide, Adelaide, Australia; 4III Medizinische Klinik,(More)
Our aim was to identify variation in surgical technique for treating pelvic floor disorders looking specifically at differences in approach between subspeciality trained urogynaecologists and general gynaecologists. We hypothesised that speciality trained surgeons would have a more uniform operative technique. We did not make a hypothesis about which(More)
http://bloodjournal.hematologylibrary.org/content/111/8/4022.full.html Updated information and services can be found at: (4217 articles) Neoplasia • (3667 articles) Clinical Trials and Observations • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests(More)
Antisense oligodeoxynucleotide (ODN) drugs might be more effective if their delivery was optimized and they were targeted to short-lived proteins encoded by messenger RNA (mRNA) species with equally short half-lives. To test this hypothesis, an ODN targeted to the c-myb proto-oncogene was developed and used to purge marrow autografts administered to(More)
1Oregon Health & Science University Knight Cancer Institute, Portland; 2Academic Haematology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom; 3Gene Microarray Shared Resource, Oregon Health & Science University, Portland; 4Clinical Programs, Pathwork Diagnostics, Redwood City, CA; 5Integrative Computational Sciences, Lilly Singapore(More)