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Spatially-tiled architectures, such as Coarse-Grained Reconfigurable Arrays (CGRAs), are powerful architectures for accelerating applications in the digital-signal processing, embedded, and scientific computing domains. In contrast to Field-Programmable Gate Arrays (FPGAs), another common accelerator, they typically time-multiplex their processing elements(More)
The ability to build maps of indoor environments is extremely important for autonomous mobile robots. In this paper we introduce Voronoi random fields (VRFs), a novel technique for mapping the topological structure of indoor environments. Our maps describe environments in terms of their spatial layout along with information about the different places and(More)
Fibroblast growth factor 1 (FGF-1) is a potent angiogenic and neurotrophic factor whose structure lacks a classical signal sequence for secretion. Although the initiation of these biological activities involves the interaction between FGF-1 and cell surface receptors, the mechanism responsible for the regulation of FGF-1 secretion is unknown. We report that(More)
Nuclear localization of fibroblast growth factors (FGF) have been reported by many laboratories. We demonstrate here that FGF-1, the precursor for acidic FGF contains a putative nuclear translocation sequence (NTS) NYKKPKL, which is able to direct the expression of the bacterial beta galactosidase (beta gal) gene to the nucleus of transfected NIH 3T3 cells.(More)
Fibroblast growth factor (FGF)-1(1-154), the precursor for acidic FGF-1(21-154), is a potent angiogenic polypeptide, the structure of which lacks a signal peptide sequence for secretion. To investigate the biological significance of this structural feature, we have attempted forced secretion of FGF-1 through fusion of the entire FGF-1 coding frame with the(More)
In this paper we present SPR, a new architecture-adaptive mapping tool for use with Coarse-Grained Reconfigurable Architectures (CGRAs). It combines a VLIW style scheduler and FPGA style placement and pipelined routing algorithms with novel mechanisms for integrating and adapting the algorithms to CGRAs. We introduce a latency padding technique that(More)
Fibroblast growth factor (FGF)-1 is released from NIH 3T3 cells in response to heat shock as a biologically inactive protein that is unable to bind heparin and requires activation by (NH4)2SO4 to generate a biologically active extracellular heparin-binding growth factor (Jackson, A., Friedman, S., Zhan, X., Engleka, K. A., Forough, R., and Maciag, T. (1992)(More)
Coarse-grained reconfigurable architectures (CGRAs) have the potential to offer performance approaching an ASIC with the flexibility, within an application domain, similar to a digital signal processor. In the past, coarse-grained reconfigurable architectures have been encumbered by challenging programming models that are either too far removed from the(More)
While the prototype members of the fibroblast growth factor (FGF) family, FGF-1 and FGF-2 are structurally related, the structural differences between these polypeptides predict that they will ultimately exhibit different biological roles. Indeed, a significant difference between these proteins is the dependence of FGF-1 on heparin for the generation of(More)