Stephen F. Vatner

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Sirt1 regulates aging and resistance to oxidative stress in the heart.

Ralph R. Alcendor, Shumin Gao, +7 authors Junichi Sadoshima
Circulation research
2007

Silent information regulator (Sir)2, a class III histone deacetylase, mediates lifespan extension in model organisms and prevents apoptosis in mammalian cells. However, beneficial functions of Sir2… (More)

Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress

Lin Yan, Dorothy E. Vatner, +7 authors Stephen F. Vatner
Cell
2007

Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are… (More)

Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

Shweta Rane, Minzhen He, +6 authors M. L. Abdellatif
Circulation research
2009

MicroRNAs are posttranscriptional gene regulators that are differentially expressed during various diseases and have been implicated in the underlying pathogenesis. We report here that miR-199a is… (More)

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

Tetsuro Ago, Tong Liu, +5 authors Junichi Sadoshima
Cell
2008

Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death. Here we studied the… (More)

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

Guy R. Heyndrickx, Ronald Wesley Millard, Robert J McRitchie, Peter R. Maroko, Stephen F. Vatner
The Journal of clinical investigation
1975

The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. Total… (More)

Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.

Ralph R. Alcendor, Lorrie A. Kirshenbaum, Shin-ichiro Imai, Stephen F. Vatner, Junichi Sadoshima
Circulation research
2004

Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) and founding member of the HDAC class III family, functions in a wide array of… (More)

Autophagy in chronically ischemic myocardium.

Lin Yan, Dorothy E. Vatner, +7 authors Stephen F. Vatner
Proceedings of the National Academy of Sciences…
2005

We tested the hypothesis that chronically ischemic (IS) myocardium induces autophagy, a cellular degradation process responsible for the turnover of unnecessary or dysfunctional organelles and… (More)

Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine.

Weiqun Shen, Kuniya Asai, +4 authors Joanne S. Ingwall
Circulation
1999

BACKGROUND Whether myocardial ATP content falls in heart failure is a long-standing and controversial issue. The mechanism(s) to explain any decrease in ATP content during heart failure have not been… (More)

The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes.

Carmine Morisco, David C. Zebrowski, Gianluigi Condorelli, Philip N Tsichlis, Stephen F. Vatner, Junichi Sadoshima
The Journal of biological chemistry
2000

We examined the mechanism of atrial natriuretic factor (ANF) transcription by isoproterenol (ISO), an agonist for the beta-adrenergic receptor (betaAR), in cardiac myocytes. ISO only modestly… (More)

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

Shimako Yamamoto, Guiping Yang, +12 authors Junichi Sadoshima
The Journal of clinical investigation
2003

Activation of mammalian sterile 20-like kinase 1 (Mst1) by genotoxic compounds is known to stimulate apoptosis in some cell types. The importance of Mst1 in cell death caused by clinically relevant… (More)

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