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OBJECTIVES NanoDisk-amphotericin B (ND-AMB) is a protein-phospholipid bioparticle containing a "super aggregate" form of antifungal AMB. While lipid-based formulations of AMB, including liposomal AMB (L-AMB), are safer than the deoxycholate (DOC) solubilized form (DOC-AMB), the potency of lipid-based formulations is attenuated. We have developed an(More)
BACKGROUND Meningococcal sepsis remains an important cause of morbidity and mortality. We hypothesised that children with severe meningococcaemia might benefit from inhibition of the inflammatory processes thought responsible for fulminant disease. rBPI21 is a recombinant, N-terminal fragment of human bactericidal/permeability-increasing protein, which(More)
HYPOTHESIS Preoperative and intraoperative variables predict in part adverse outcome after liver transplantation. DESIGN Prospective, blinded, cohort study. SETTING Tertiary care hospital. SUBJECTS A total of 190 adult patients undergoing primary liver transplantation. MAIN OUTCOME MEASURE Adverse outcome was prospectively defined as either(More)
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