Stephen Emmott

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The gene regulatory circuitry through which pluripotent embryonic stem (ES) cells choose between self-renewal and differentiation appears vast and has yet to be distilled into an executive molecular program. We developed a data-constrained, computational approach to reduce complexity and to derive a set of functionally validated components and interaction(More)
SUMMARY The Visual DSD (DNA Strand Displacement) tool allows rapid prototyping and analysis of computational devices implemented using DNA strand displacement, in a convenient web-based graphical interface. It is an implementation of the DSD programming language and compiler described by Lakin et al. (2011) with additional features such as support for(More)
The feedback between climate and the terrestrial carbon cycle will be a key determinant of the dynamics of the Earth System (the thin layer that contains and supports life) over the coming decades and centuries. However, Earth System Model projections of the terrestrial carbon-balance vary widely over these timescales. This is largely due to differences in(More)
S oftware pervades every domain of science ( 1– 3), perhaps nowhere more decisively than in modeling. In key scientifi c areas of great societal importance, models and the software that implement them defi ne both how science is done and what science is done ( 4, 5). Across all science, this dependence has led to concerns around the need for open access to(More)
Such models could capture the broad-scale structure and function of any ecosystem in the world by simulating processes — including feeding, reproduction and death — that drive the distribution and abundance of organisms within that ecosystem. Ecologists could apply a GEM to African savannas, for instance, to model the total biomass of all the plants, the(More)
Artificially implementing the biological light reactions responsible for the remarkably efficient photon-to-charge conversion in photosynthetic complexes represents a new direction for the future development of photovoltaic devices. Here, we develop such a paradigm and present a model photocell based on the nanoscale architecture and molecular elements of(More)
The rational design of synthetic cell populations with prescribed behaviours is a long-standing goal of synthetic biology, with the potential to greatly accelerate the development of biotechnological applications in areas ranging from medical research to energy production. Achieving this goal requires well-characterized components, modular implementation(More)
AFFILIATIONS: SMith, PurveS, lyutSarev, JoPPa, biShoP, anD eMMott—Microsoft Research, Cambridge, United Kingdom; PalMer—Microsoft Research, Cambridge, and School of GeoSciences, University of Edinburgh, Edinburgh, United Kingdom; vanDerwel—Microsoft Research, Cambridge, United Kingdom, and Department of Biology, University of Florida, Gainesville, Florida;(More)
1 Computational Biology Group, Department of Computer Science, University of Oxford, Wolfson Building, Oxford, United Kingdom, 2 Computational Science Laboratory, Microsoft Research, Cambridge, United Kingdom, 3 CoMPLEX, Mathematical and Physical Sciences, University College London, Physics Building, London, United Kingdom, 4 Centre for Computational(More)
Neuronal migration, the process by which neurons migrate from their place of origin to their final position in the brain, is a central process for normal brain development and function. Advances in experimental techniques have revealed much about many of the molecular components involved in this process. Notwithstanding these advances, how the molecular(More)