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Previous studies have correlated the failure of axon regeneration after spinal cord injury with axons contacting scar tissue rich in chondroitin sulfate proteoglycans (CSPGs; Davies et al., 1999). In the present study, we have conducted immunohistochemical and quantitative Western blot analysis of five axon-growth-inhibitory CSPGs and tenascin-C within stab(More)
Repairing trauma to the central nervous system by replacement of glial support cells is an increasingly attractive therapeutic strategy. We have focused on the less-studied replacement of astrocytes, the major support cell in the central nervous system, by generating astrocytes from embryonic human glial precursor cells using two different astrocyte(More)
The formation of misaligned scar tissue by a variety of cell types expressing multiple axon growth inhibitory proteoglycans presents a physical and molecular barrier to axon regeneration after adult spinal cord injuries. Decorin is a small, leucine-rich proteoglycan that has previously been shown to reduce astrogliosis and basal lamina formation in acute(More)
Inhibitory chondroitin sulfate proteoglycans (CSPGs) and myelin-associated molecules are major impediments to axon regeneration within the adult central nervous system (CNS). Decorin infusion can however suppress the levels of multiple inhibitory CSPGs and promote axon growth across spinal cord injuries [Davies, J.E., Tang, X., Denning, J.W., Archibald,(More)
Spinal cord scar tissue presents a combined physical and molecular barrier to axon regeneration. Theoretically, spinal cord injuries (SCIs) can be rendered more permissive to axon growth by either suppressing synthesis of misaligned, fibrotic scar tissue and associated axon growth inhibitors, or enzymatically degrading them. We have previously shown that(More)
This review summarizes current progress on development of astrocyte transplantation therapies for repair of the damaged central nervous system. Replacement of neurons in the injured or diseased central nervous system is currently one of the most popular therapeutic goals, but if neuronal replacement is attempted in the absence of appropriate supporting(More)
If non-technical end users are to contribute to the Web of Data as they have to the Web of Documents, they must employ tools that enable them to do so. This challenge is not easy to meet, as formal knowledge representation is a daunting task for the uninitiated. Indeed, we have empirically observed that expressing anything but the most straightforward of(More)
People often use powerful tools to manage the documents they encounter, but very rarely to store the mental knowledge they glean from those documents. Popcorn is a <i>personal knowledge base</i>: an experimental interface and database designed to store and retrieve a user's accumulated personal knowledge. It aims to let the user represent information in a(More)
We present results from a nationwide survey of undergraduate computer science departments regarding languages and techniques taught in CS0, CS1, and CS2. This snapshot of 371 schools provides an intriguing look into the state of computing education today in the U.S., quantifying which practices are actually in common use. Among other things, the study(More)