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- Peter Kuehl, Jiong Zhang, +16 authors Erin G. Schuetz
- Nature Genetics
- 2001
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum activity of… (More)
- Samir K Gupta, Joseph A. Eustace, +12 authors Lynda A. Szczech
- Clinical infectious diseases : an official…
- 2005
Samir K. Gupta, Joseph A. Eustace, Jonathan A. Winston, Ivy I. Boydstun, Tejinder S. Ahuja, Rudolph A. Rodriguez, Karen T. Tashima, Michelle Roland, Nora Franceschini, Frank J. Palella, Jeffrey L.… (More)
- Bryan A Ward, Jude Christopher Gorski, David R. Jones, Stephen D. Hall, David A. Flockhart, Zeruesenay Desta
- The Journal of pharmacology and experimental…
- 2003
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to identify the routes of efavirenz metabolism and the P450s involved. In HLMs, efavirenz undergoes primary oxidative… (More)
- Brent Mayhew, David R. Jones, Stephen D. Hall
- Drug metabolism and disposition: the biological…
- 2000
An in vitro model is proposed to account for the clinically observed inhibition of cytochrome P450 (CYP) 3A that results from administration of clarithromycin, fluoxetine, or diltiazem. Rates for… (More)
- Jude Christopher Gorski, David R. Jones, Barbara Haehner-Daniels, Mitchell A. Hamman, Edward M O'Mara, Stephen D. Hall
- Clinical pharmacology and therapeutics
- 1998
OBJECTIVE
To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the prototypic CYP3A substrates midazolam and clarithromycin.
METHODS
On day 1,… (More)
- Yinghong Wang, David R. Jones, Stephen D. Hall
- Drug metabolism and disposition: the biological…
- 2004
Verapamil inhibition of CYP3A activity results in many drug-drug interactions with CYP3A substrates, but the mechanism of inhibition is unclear. The present study showed that verapamil enantiomers… (More)
- Jun Zhang, Peter Kuehl, +17 authors Mark S. Boguski
- Pharmacogenetics
- 2001
The pregnane X receptor (PXR)/steroid and xenobiotic receptor (SXR) transcriptionally activates cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. We cloned the human… (More)
- Jennifer A E Williams, Barbara J. Ring, +6 authors Steven A. Wrighton
- Drug metabolism and disposition: the biological…
- 2002
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent evidence indicates that CYP3A5… (More)
- Mitchell A. Hamman, Guy A. Thompson, Stephen D. Hall
- Biochemical pharmacology
- 1997
The cytochrome P450s responsible for the regio- and stereoselectivity in the 2- and 3-hydroxylation of the chiral non-steroidal antiinflammatory drug ibuprofen were characterized in human liver… (More)
- Jude Christopher Gorski, S Huang, +6 authors Stephen D. Hall
- Clinical pharmacology and therapeutics
- 2004
BACKGROUND
Echinacea is a widely available over-the-counter herbal remedy. Tinctures of echinacea have been shown to inhibit cytochrome P450 (CYP) in vitro. The effect of echinacea (Echinacea… (More)