Stephen D. Cramer

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A 20-fold increase in the relative expression of the hepatic GH-binding protein (GHBP)-encoding message between nonpregnant and 17-day pregnant mice was found. The hepatic GH receptor (GHR)-encoding message increased 8-fold between nonpregnant and pregnant mice. The increase in both messages began on day 9 of pregnancy. The steady state level of the(More)
A RIA for mouse growth hormone-binding protein (mGHBP) was developed. A 28-amino acid synthetic peptide corresponding to the carboxyl-terminal 27 amino acids of mGHBP plus an additional cysteine residue at the amino-terminus was coupled to keyhole limpet hemocyanin and used as the antigen for antiserum production. The ability of the antiserum to recognize(More)
The Severe Environment Corrosion and Erosion Research Facility (SECERF) at the Albany Research Center is operational. SECERF consists of 6 modules that share the availability of up to 10 different gases to produce environments for high temperature corrosion and erosion research. Projects to be conducted in the modules include: corrosion sensors for fossil(More)
The regulation of hepatic GH receptor (GHR) and serum GH-binding protein (GHBP) during pregnancy in the mouse was investigated by manipulating the number of conceptuses carried by the dam. Animals carrying 1-4 conceptuses had significantly lower amounts of hepatic GHR (GH-binding activity) than mice carrying 10-13 conceptuses on days 9 and 13 of pregnancy.(More)
GH-binding protein (GHBP) or GH receptor is present in numerous extrahepatic tissues in the rodent. From mid- to late gestation in the mouse, the maternal serum concentration of GHBP increases 30- to 50-fold. We have investigated whether the placenta might synthesize GHBP and potentially contribute to this increase. RNA was isolated from placentas and(More)
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