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The present study provides evidence that v alence focus and arousal focus are important processes in determining w hether a dimensional or a discrete emotion model best captures how people label their affective states. Individuals high in valence focus and low in arousal focus ® t a dimensional model better in that they reported more co-oc currences among(More)
Parkinson's disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem cell (iPSC) technology for PD disease modeling using the twins' fibroblasts to evaluate(More)
Typical reconfigurable computing systems are based on an I/O interconnect such as PCIe. This yields good bandwidth performance, but incurs significant overhead for small packet sizes, and makes the implementation of on-streaming-data applications unduly difficult. We describe an architecture based on Intel R Quick Path Interconnect R that addresses these(More)
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic variants impact cellular function in disease, as well as an emerging source of tissue for regenerative medicine. The preparation of somatic cells, their reprogramming and the subsequent verification of iPSC pluripotency are laborious, manual processes limiting the(More)
Knockout mice deficient in the gap junction gene connexin43 exhibit developmental anomalies associated with abnormal neural crest, primordial germ cell, and proepicardial cell migration. These migration defects are due to a loss of directional cell movement, and are associated with abnormal actin stress fiber organization and a loss of polarized cell(More)
INTRODUCTION Human umbilical cord blood (UCB) has been used as a reliable source of stem cells for blood-borne diseases and disorders. Recent advances in cell reprogramming technology to produce induced pluripotent stem (iPS) cells, which can be differentiated to multiple adult cell types, has further expanded the potential of cord blood cell therapy for(More)
While many programmers appreciate the benefits of lazy programming at an abstract level, determining which parts of a concrete program to evaluate lazily poses a significant challenge for most of them. Over the past thirty years, experts have published numerous papers on the problem, but developing this level of expertise requires a significant amount of(More)
In artificial pancreas, glucose level measurement and insulin infusion are often implemented in the subcutaneous tissues. Understanding the dynamics of glucose and insulin in the subcutaneous tissues is important in the regulation of blood glucose level. We propose a new two-compartmental model of glucose-insulin interaction with two explicit delays that(More)
Ariola and Felleisen's call-by-need λ-calculus replaces a variable occurrence with its value at the last possible moment. To support this gradual notion of substitution, function applications—once established—are never discharged. In this paper we show how to translate this notion of reduction into an abstract machine that resolves variable references via(More)