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Chemically induced long-term potentiation (cLTP) could potentially work by directly stimulating the biochemical machinery that underlies synaptic plasticity, bypassing the need for synaptic activation. Previous reports suggested that agents that raise cAMP concentration might have this capability. We examined the cLTP induced in acute slices by application(More)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a leading candidate for a synaptic memory molecule because it is persistently activated after long-term potentiation (LTP) induction and because mutations that block this persistent activity prevent LTP and learning. Previous work showed that synaptic stimulation causes a rapidly reversible(More)
  • Michael L Pace, Jonathan J Cole, Stephen R Carpenter, James F Kitchell, Colej@ecostudies, Stephen Carpenter +1 other
  • 1999
483 REVIEWS 'S ince then I have lived to see state after state extirpate its wolves. I have watched the face of many a new wolfless mountain , and seen the south-facing slopes wrinkle with a maze of new deer trails. I have seen every edible bush and seedling browsed, first to anemic desuetude, and then to death. I have seen every edible tree defoli-ated to(More)
Lake consumers are supported by autoch-thonous organic matter produced by photosynthesis within the aquatic ecosystem and imported allochth-onous material produced outside the ecosystem. To evaluate carbon sources that support fish growth, we enriched a 26 ha lake with inorganic 13 C. This labeled the autochthonous primary production and allowed us to(More)
Ensemble, the National Science Digital Library (NSDL) Pathways project for Computing, builds upon a diverse group of prior NSDL, DL-I, and other projects. Ensemble has shaped its activities according to principles related to design, development, implementation, and operation of distributed portals. Here we articulate 8 key principles for distributed portals(More)
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