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  • Stephen C Bunnell, Vaishali Kapoor, Ronald P. Trible, W. Zhang, Lawrence E Samelson
  • Biology, Medicine
  • Immunity
  • 2001 (First Publication: 1 March 2001)
  • T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells onExpand
  • Stephen C Bunnell, Maximilian Diehn, Michael B. Yaffe, Paul R. Findell, Lewis C. Cantley, Leslie J Berg
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000 (First Publication: 21 January 2000)
  • Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3′-kinase to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-regulatedExpand
  • S D Heyeck, Heather M Wilcox, Stephen C Bunnell, Leslie J Berg
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 1997 (First Publication: 3 October 1997)
  • The Tec family tyrosine kinase Itk has been implicated in T cell receptor (TCR) signaling, yet its precise role and mechanism of activation remain undefined. To investigate these issues, we examinedExpand
  • Xiaochuan Shan, Michael J. Czar, +4 authors Ronald L. Wange
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 2000 (First Publication: 15 September 2000)
  • ABSTRACT Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant changeExpand