Stephen Booth

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Experimental autoimmune encephalomyelitis (EAE) is induced in the SJL/J mouse by adoptive transfer of activated proteolipid protein peptide (PLP) 139-151-specific Th1 cells. T cells responding to altered peptide ligands (APL) of PLP, previously shown to induce Th2 differentiation and regulate disease in PLP-immunized mice, do not transfer EAE. However, the(More)
We present the initial results from the FHPCA Supercomputer project at the University of Edinburgh. The project has successfully built a general-purpose 64 FPGA computer and ported to it three demonstration applications from the oil, medical and finance sectors. This paper describes in brief the machine itself – Maxwell – its hardware and software(More)
This paper reviews the current state of the art in highperformance reconfigurable computing (HPRC) from the perspective of EPCC, the high-performance computing centre at the University of Edinburgh. We look at architectural and programming trends and assess some of the challenges that HPRC needs to address in order to drive itself across the chasm from the(More)
We describe the FPGA HPC Alliance’s Parallel Toolkit (PTK), an initial step towards the standardization of high-level configuration and APIs for high-performance reconfigurable computing (HPRC). We discuss the motivation and challenges of reaping the performance benefits of FPGAs for memory-bound HPC codes and describe the approach we have taken on the(More)
Pulmonary lymphangioleiomyomatosis (PLAM) is an indication for lung transplantation (LTx). Angiomyolipomas occur in approximately 50% to 60% of patients with PLAM. We describe a patient presenting with hemoptysis post-LTx for PLAM. Computed tomography (CT) scan demonstrated no pulmonary abnormality, but identified a retroperitoneal mass confirmed as(More)
We discuss the design and implementation of a parallel adaptive PM code, for massively parallel architectures. The code, although primarily designed for conducting gravitational simulations in a cosmological context, also includes a Smoothed Particle Hydrodynamics solver. The code is written in a combination of C, FORTRAN 77 and FORTRAN 90. The MPI-2 remote(More)
Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity. As serum factors might be responsible, we examined the effects of autologous post-exercise serum exposure on TLR2, TLR4 and HLA.DR expression on resting blood monocytes and their subtypes. Eight trained(More)