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Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neurons, which results in weakness and atrophy of voluntary skeletal muscles. Treatments do not modify theExpand
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Association of Environmental Toxins With Amyotrophic Lateral Sclerosis.
IMPORTANCE Persistent environmental pollutants may represent a modifiable risk factor involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluateExpand
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Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression
Importance Amyotrophic lateral sclerosis (ALS) has an immune component, but previous human studies have not examined immune changes over time. Objectives To assess peripheral inflammatory markers inExpand
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Transplantation of spinal cord–derived neural stem cells for ALS
Objective: To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multipleExpand
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Environmental Risk Factors and Amyotrophic Lateral Sclerosis (ALS): A Case-Control Study of ALS in Michigan
An interim report of a case-control study was conducted to explore the role of environmental factors in the development of amyotrophic lateral sclerosis (ALS). Sixty-six cases and 66 age- andExpand
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Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis
Objective: To elucidate amyotrophic lateral sclerosis (ALS) biomarkers and potential mechanisms of disease, we measured immune cell populations in whole blood from a large cohort of patients withExpand
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Long‐term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS
Intraspinal human spinal cord‐derived neural stem cell (HSSC) transplantation is a potential therapy for amyotrophic lateral sclerosis (ALS); however, previous trials lack controls. This post hocExpand
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Painful diabetic neuropathy
Diabetes is a worldwide epidemic, and associated neuropathy is its most costly and disabling complication. Given the rising prevalence of painful diabetic neuropathy, it is increasingly importantExpand
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Diagnosis and Clinical Management of Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
ABSTRACT Purpose of Review: This article reviews the clinical features, diagnostic pathway, therapies, and current understanding of the pathophysiology of amyotrophic lateral sclerosis (ALS). TheExpand
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Complete hazard ranking to analyze right-censored data: An ALS survival study
In this study, we developed GuanRank, a non-parametric ranking-based technique to transform patients' survival data into a linear space of hazard ranks. Expand
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