Stephen A. Kelly

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Proinflammatory cytokines upregulate endothelial adhesion molecule expression, thereby initiating the microvascular inflammatory response. We re-evaluated the reported role of reactive oxygen metabolites (ROMs) in signalling upregulation of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by tumour necrosis factor alpha (TNF-alpha) in vitro.(More)
BACKGROUND Stakeholders suggest that integrating end users into the planning and execution of quality improvement interventions may more effectively close quality gaps. We tested if such an approach could improve the quality of colorectal cancer surgery in a large geographic region (i.e., LHIN4) in Ontario, Canada. METHODS All LHIN4 surgeons who provide(More)
OBJECTIVES The National Strategy for Sexual Health and HIV aims to facilitate improved patient access to sexual health care, primarily in general practice. This study aimed to identify sexual health care provision in general practitioner (GP) training practices and highlight training and resource implications of the strategy for GPs and prospective GPs. (More)
SUMMARY A highly unusual algae bloom has persisted in eastern Florida Bay and southern Biscayne Bay (Manatee Bay, Barnes Sound, and Card Sound) since at least November 2005. Similar algae blooms have been observed in central and western Florida Bay, but never in eastern Florida Bay. Chlorophyll a concentrations (an indicator of the amount of algae in the(More)
Proinflammatory cytokines initiate the vascular inflammatory response via the upregulation of adhesion molecules on the luminal endothelial surface. We investigated directly the role of protein tyrosine phosphorylation in the upregulation of the endothelial adhesion molecules, intercellular adhesion molecule 1 (ICAM-1) and E-selectin, and the consequent(More)
ACKNOWLEDGEMENTS The editors would like to thank the British Council in Belfast, and in particular its director Mr Colm McGivern, for providing support for the conference at which these essays originated. The Research Office at Queen's University also provided considerable support, for which we are grateful. The School of English and the School of(More)
Although site safety has long been a key research topic in the construction field, there is a lack of literature studying safety management practices (SMPs). The current research, therefore, aims to test the effect of SMPs on project performance. An empirical study was conducted in Hong Kong and the data collected were analysed with multiple regression(More)
This study was conducted to determine whether inhibitors of normal cellular functions can reduce cytotoxicity induced by sulfur mustard (HD). The compounds examined include inhibitors of poly(ADP-ribose) polymerase (PADPRP), inhibitors of mono(ADP-ribose) transferase (MADPRT), inhibitors of lipid peroxidation, and an inhibitor of protein synthesis. To(More)
[reaction: see text]. Upon treatment with n-BuLi at low temperatures, a variety of allyl 1,1-dichlorovinyl ethers 2 undergo rearrangement to furnish gamma,delta-unsaturated esters 3 after alcohol addition. Compounds containing quaternary centers (3e: R1 = H, R2, R3 = -(CH2)5-; 3f: R1 = H, R2 = CH3, R3 = (CH2)2CH(CH3)2) may be formed in high yield and under(More)
The study was undertaken to look at adolescents' experiences in school sexual education programs, to examine how abstinence only and comprehensive sexual education programs impact adolescent sexual behavior, and to explore whether there is a correlation between adolescents' sexual behavior and their satisfaction with their sexual health education. This(More)