Stephen A. Bloom

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Partial agonist therapies rely variously on two hypotheses: the partial agonists have their effects through chronic low-level receptor activation or the partial agonists work by decreasing the effects of endogenous or exogenous full agonists. The relative significance of these activities probably depends on whether acute or chronic effects are considered.(More)
Habitat and food resource partitioning ecologically isolate six species of Pacific Northwest dorid nudibranchs. Food resources along a gradient of sponge skeletal structure are partitioned between two exploitive guilds. The guilds are characterized by mutually exclusive predatory and digestive adaptations which allow efficient processing of sponges with(More)
Advances in the understanding of appetite are leading to a refined concept of disease cachexia and point to novel therapeutic strategies based on the manipulation of appetite. The complex social and psychological short-term influences on appetite obscure the fact that over the longer term appetite is tightly regulated by physiological considerations; the(More)
The concept of biological stability is so complex that at least six different meanings have been ascribed to it. We propose that one definition, “the ability of a system once perturbed to return to its previous state” be utilized as a working definition. Using quantitative data collected monthly from a soft-bottom community that undergoes an annual natural(More)
BACKGROUND Dual-energy CT (DECT) has potential to improve myocardial perfusion for physiologic assessment of coronary artery disease (CAD). Diagnostic performance of rest-stress DECT perfusion (DECTP) is unknown. OBJECTIVE DECIDE-Gold is a prospective multicenter study to evaluate the accuracy of DECT to detect hemodynamic (HD) significant CAD, as(More)
The key question this volume is addressing concerns the role of transnational actors in processes of democratisation in post-communist Europe which, according to the editors, is ‘the dark matter that held the various aspects of post-communist transition together in Central and East Europe’ (2008, 6). The authors represented in this volume, as well as the(More)
OBJECTIVES To evaluate the diagnostic performance and predictive value of coronary computed tomography angiography (CCTA) on subsequent cardiac outcomes. BACKGROUND CCTA has been suggested as an alternative method to invasive coronary angiography for detection of and ruling out coronary artery disease (CAD). However, the usefulness of CCTA findings in(More)