Stephanie Wisniewski

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Acne vulgaris is the result of multifactorial disorders of the pilosebaceous duct. The initial lesion is believed to be hyper-keratinization of the infundibulum. The Rhino mouse has been used as an experimental acne model system for screening anti-keratinizing and comedolytic agents. Using this system we show that trypsin could induce desquamation and(More)
We present the synthesis and characterization of the somatostatin receptor-specific peptide H(2)N-(D-Phe)-cyclo[Cys-Phe-(D-Trp)-Lys-Thr-Cys]-Thr-OH, which is labeled with a carboxylated indodicarbo- and an indotricarbocyanine dye at the N-terminal amino group. The preparation was performed by automated solid-phase synthesis, with subsequent attachment of(More)
The effects of intravesical doxorubicin on cells in superficial transitional cell carcinomas and adjacent urothelium were studied by electron microscopy. Nucleolar segregation, vacuolation of the cytoplasms, mitochondrial abnormalities and the breakdown of secondary lysosomes leading to autolysis were the main patterns of damage. Cell loss was by(More)
The ions Na+ , K+ , Ca2+ , Mg2+ , Cl- , SO42- , and HCO3- /CO32- (referred to in the present study as "major ions") are present in all freshwaters and physiologically required by aquatic organisms but can increase to harmful levels from a variety of anthropogenic activities. It is also known that the toxicities of major ion salts can vary depending on the(More)
Thrombus formation on a foreign surface is a complicated process, involving many factors. However, there is little doubt that a foreign surface adsorbs plasma proteins upon blood contact and that the nature of this adsorbed layer may determine the mechanism of platelet adhesion and aggregation. The adhesion and aggregation of platelets play an important(More)
Programmed cell death is a controlled process that leads to the elimination of single cells via apoptosis. Programmed cell death is fundamental to development, morphogenesis, and homeostasis. Proteases play a major role in the death process. We have previously shown that a serine protease, secreted by a keratinocyte cell line, can induce apoptosis in(More)
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