Learn More
Although motor deficits are common in autism, the neural correlates underlying the disruption of even basic motor execution are unknown. Motor deficits may be some of the earliest identifiable signs of abnormal development and increased understanding of their neural underpinnings may provide insight into autism-associated differences in parallel systems(More)
The large amount of imaging data collected in several ongoing multi-center studies requires automated methods to delineate brain structures of interest. We have previously reported on using artificial neural networks (ANN) to define subcortical brain structures. Here we present several automated segmentation methods using multidimensional registration. A(More)
The study compared psychosocial risk behaviors of adolescents who were deaf or hard of hearing with those of their hearing peers in a residential treatment facility. Statistically significant differences emerged between groups. The adolescents who were deaf or hard of hearing demonstrated clinically higher scores than those of their hearing peers on the(More)
The present study compared performance of children with Attention-Deficit/Hyperactivity Disorder (ADHD) and high functioning autism (HFA) with that of controls on 4 tasks assessing 2 components of motor control: motor response inhibition and motor persistence. A total of 136 children (52 ADHD, 24 HFA, 60 controls) ages 7 to 13 years completed 2 measures of(More)
BACKGROUND AND PURPOSE White matter structural alterations and the correlation with neuropsychological deficits in children with hydrocephalus have not been well investigated. In this prospective study, the objectives were the following: 1) to apply DTI to detect in vivo white matter alterations based on diffusion properties in children with acute(More)
The authors report the case of a 25-month-old boy who underwent endoscopic third ventriculostomy (ETV) for hydrocephalus resulting from aqueductal stenosis. The patient's recovery was monitored longitudinally and prospectively using MR diffusion tensor imaging (DTI) and formal neuropsychological testing. Despite minimal change in ventricle size, improvement(More)
In this paper we describe a new method for quantifying metabolic asymmetry modulo structural hemispheric differences. The study of metabolic asymmetry in Alzheimer's disease (AD) serves as a driving application. The approach is based on anatomical atlas construction by large deformation diffeomorphic metric mapping (LDDMM) first introduced in [1]. Using(More)
hemisphere structural connectivity abnormality in pediatric hydrocephalus patients following surgery. a b s t r a c t a r t i c l e i n f o Neuroimaging research in surgically treated pediatric hydrocephalus patients remains challenging due to the ar-tifact caused by programmable shunt. Our previous study has demonstrated significant alterations in the(More)
Neuroimaging research in surgically treated pediatric hydrocephalus patients remains challenging due to the artifact caused by programmable shunt. Our previous study has demonstrated significant alterations in the whole brain white matter structural connectivity based on diffusion tensor imaging (DTI) and graph theoretical analysis in children with(More)
OBJECTIVE The purpose of this study was to investigate white matter (WM) structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy) and during the course of recovery after surgery in association with(More)
  • 1